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860053P

Avanti

Ganglioside-Total

Avanti Research™ - A Croda Brand

Szinonimák:

Total Ganglioside Extract (Brain, Porcine-Ammonium Salt)

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)

About This Item

CAS-szám:
383907-71-9
UNSPSC kód:
12352211
NACRES:
NA.25

Teszt

>99% (TLC)

form

powder

kiszerelés

pkg of 1 × 10 mg (860053P-10mg)
pkg of 1 × 25 mg (860053P-25mg)
pkg of 1 × 50 mg (860053P-50mg)

gyártó/kereskedő neve

Avanti Research™ - A Croda Brand

lipidtípus

sphingolipids

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

SMILES string

[H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@@]([H])(NC(CCCCCCCCCCCCCCCCC)=O)CO[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2O[C@H](CO)[C@@H]([C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O)CO)[C@@](NC(C)=O)([H])[C@@H](O)C3)[C@H]2O)O[C@@H]4O[C@H](CO)[C@@H]([C@H](O[C@@H]5O[C@H

Általános leírás

Gangliosides are glycosphingolipids, that contain sialic acid residues in the glycan chain. They are mainly present on the surface of neuronal cells. Gangliosides are also present in serum. Four complex ganglioside structures, such as GM1, GD1a, GD1b and GT1b are the most abundantly found ganglioside in mammalian brains. Gangliosides comprise a ceramide tail attached to a polar carbohydrate head.

Alkalmazás

Ganglioside-Total may be used:
  • as a standard to investigate the efficiency of ganglioside extraction in brain using electrospray ionization-mass spectrometry (ESI MS) analysis
  • as a hemagglutinin (HA) binding receptor to assemble nanodisc with affinity to influenza virus (NDTG) and also to determine the effect of total ganglioside extract (TG) amount on total ganglioside
  • in liposomes to measure ostreolysin A (OlyA) binding in order to deduce the effects of phosphatidylcholines (PCs) on sphingomyelin

Biokémiai/fiziológiai hatások

Gangliosides regulate various biological activities in cell plasma membranes (PMs). It provides structural rigidity to the cell. Ganglioside clusters form membrane microdomains, which facilitates cell adhesion. It also functions as differentiating markers during oncogenesis, embryogenesis, lymphoid differentiation and neoplastic transformation. Gangliosides have the ability to repress cell-mediated immune functions. It is also associated with cancer and Alzheimer′s disease.

Kiszerelés

5 mL Amber Glass Screw Cap Vial (860053P-10mg)
5 mL Amber Glass Screw Cap Vial (860053P-25mg)
5 mL Amber Glass Screw Cap Vial (860053P-50mg)

Jogi információk

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Tárolási osztály kódja

11 - Combustible Solids

WGK

WGK 3

Lobbanási pont (F)

No data available

Lobbanási pont (C)

No data available

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Dokumentumtár megtekintése

Jin Liu et al.
Biophysical journal, 89(4), 2522-2532 (2005-08-09)
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Byung-Hwan Lee et al.
Neuroscience letters, 612, 256-260 (2015-12-27)
Ginseng has a long history of use as a tonic for restoration of vigor. One example of ginseng-derived tonic effect is that it can improve physical stamina under conditions of stress. However, the active ingredient and the underlying molecular mechanism
Raphael Dos Santos Morais et al.
Biophysical journal, 115(7), 1231-1239 (2018-09-11)
Scaffolding proteins play important roles in supporting the plasma membrane (sarcolemma) of muscle cells. Among them, dystrophin strengthens the sarcolemma through protein-lipid interactions, and its absence due to gene mutations leads to the severe Duchenne muscular dystrophy. Most of the
Thomas Kolter
ISRN biochemistry, 2012, 506160-506160 (2012-01-01)
Gangliosides are sialic acid-containing glycosphingolipids. They occur especially on the cellular surfaces of neuronal cells, where they form a complex pattern, but are also found in many other cell types. The paper provides a general overview on their structures, occurrence
Petru Niga et al.
Journal of colloid and interface science, 526, 230-243 (2018-05-08)
Vibrational sum frequency spectroscopy (VSFS) complemented by surface pressure isotherm and neutron reflectometry (NR) experiments were employed to investigate the interactions between propofol, a small amphiphilic molecule that currently is the most common general anaesthetic drug, and phospholipid monolayers. A
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