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A8980

Acarbose

≥95% (HPLC)

Sinónimos:

4",6"-Dideoxy-4"-([1S]-[1,4,6/5]-4,5,6-trihydroxy-3-hydroxymethyl-2-yclohexenylamino)-maltotriose

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Acerca de este artículo

Fórmula empírica (notación de Hill):
C25H43NO18
Número CAS:
56180-94-0
Peso molecular:
645.60
NACRES:
NA.25
PubChem Substance ID:
329771024
UNSPSC Code:
12352201
EC Number:
260-030-7
MDL number:
MFCD00869592
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biological source

bacterial (Actinoplanes)

Quality Level

200

assay

≥95% (HPLC)

form

powder

impurities

<9.4% water (Karl Fischer)

color

white to off-white

solubility

H2O (CO2 free): 50 mg/mL, clear, colorless

storage temp.

room temp

SMILES string

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@@H]2CO)O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]4C=C(CO)[C@@H](O)[C@H](O)[C@H]4O

InChI

1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1

InChI key

XUFXOAAUWZOOIT-SXARVLRPSA-N

Gene Information

human ... AMY2A(279), MGAM(8972)

Application

Acarbose, a derivitized maltotriose antidiabetic drug, is a reversible α-glucosidase inhibitor used in medical studies to control the effects of Type II diabetes. Acarbose is often used as a reference to which other α-glucosidase inhibitors are compared.

Biochem/physiol Actions

Modified tetrasaccharide that acts as a reversible α -glucosidase inhibitor.

Other Notes

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Este artículo
C9008PZ0362SML0493
Acarbose &#8805;95% (HPLC)

Sigma-Aldrich

A8980

Acarbose

p-Coumaric acid &#8805;98.0% (HPLC)

Sigma-Aldrich

C9008

p-Coumaric acid

CP-640186 hydrochloride &#8805;95% (HPLC)

Sigma-Aldrich

PZ0362

CP-640186 hydrochloride

T16Ainh-A01 &#8805;95% (HPLC)

Sigma-Aldrich

SML0493

T16Ainh-A01

biological source

bacterial (Actinoplanes)

biological source

-

biological source

-

biological source

-

assay

≥95% (HPLC)

assay

≥98.0% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

solubility

H2O (CO2 free): 50 mg/mL, clear, colorless

solubility

ethanol: 50 mg/mL

solubility

H2O: 2 mg/mL, clear (warmed)

solubility

DMSO: 5 mg/mL, clear (warmed)

Quality Level

200

Quality Level

200

Quality Level

100

Quality Level

100

form

powder

form

powder

form

powder

form

powder

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000524856
0000524856
0000516275
0000516275
WXBF7363V

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Patrick Schwientek et al.
BMC genomics, 13, 112-112 (2012-03-27)
Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As the incidence of diabetes is rapidly rising worldwide, an ever increasing demand
Ashley S Boath et al.
Food chemistry, 135(3), 929-936 (2012-09-08)
Polyphenol-rich extracts from certain berries inhibited α-glucosidase activity in vitro. The two most effective berry extracts, from black currant and rowanberry, inhibited α-glucosidase with IC(50) values respectively of 20 and 30μg GAE/ml and were as effective as the pharmaceutical inhibitor
Alessandro Leone et al.
Nutrients, 10(10) (2018-10-17)
The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and
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Número de artículo de comercio global

SKUGTIN
A8980-1G04061835512157

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. What is the half life of this drug? Can we prepare 10mL and store it for weeks?

    1 answer

    1. Unfortunately, the half life and the solution stability is not determined for this product.

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