Key Documents

Propranolol hydrochloride

Name: Propranolol hydrochloride
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

(±)-Propranolol hydrochloride, (±)-1-Isopropylamino-3-(1-naphthyloxy)-2-propanol hydrochloride, DL-Propranolol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₂₁NO₂ · HCl

CAS Number:

318-98-9

Molecular Weight:

295.80

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329750990

MDL number:

MFCD00012558

Beilstein/REAXYS Number:

4164259

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Properties

grade

pharmaceutical primary standard

API family

propranolol

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

SMILES string

Cl.CC(C)NCC(O)COc1cccc2ccccc12

InChI

1S/C16H21NO2.ClH/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16;/h3-9,12,14,17-18H,10-11H2,1-2H3;1H

InChI key

ZMRUPTIKESYGQW-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154)

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Sales restrictions may apply.

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This Item	PHR1308	Y0002135	P3500000
USP 1576005 Propranolol hydrochloride	Supelco PHR1308 Propranolol hydrochloride	Y0002135 Propranolol for system suitability	P3500000 Propranolol hydrochloride
manufacturer/tradename USP	manufacturer/tradename -	manufacturer/tradename EDQM	manufacturer/tradename EDQM
grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade -	grade pharmaceutical primary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical	application(s) pharmaceutical (small molecule)
format neat	format neat	format -	format neat
Gene Information human ... ADRB1(153), ADRB2(154)	Gene Information human ... ADRB1(153), ADRB2(154)	Gene Information human ... ADRB1(153), ADRB2(154)	Gene Information human ... ADRB1(153), ADRB2(154)
API family propranolol	API family propranolol	API family propranolol	API family propranolol

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pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

pcodes

P264 - P270 - P301 + P312 - P501

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Treatment of infantile hemangiomas with propranolol: clinical guidelines.

Pawel Szychta et al.

Plastic and reconstructive surgery, 133(4), 852-862 (2013-12-20)

Infantile hemangioma is a vascular tumor and requires treatment in lesions manifested by potentially dangerous symptoms. Several publications have reported that involution of infantile hemangioma could be accelerated by propranolol but have used only invalidated subjective measures of assessment. The

Combining the α1 -adrenergic receptor antagonist, prazosin, with the β-adrenergic receptor antagonist, propranolol, reduces alcohol drinking more effectively than either drug alone.

Dennis D Rasmussen et al.

Alcoholism, clinical and experimental research, 38(6), 1532-1539 (2014-06-04)

Evidence suggests that activation of the noradrenergic system may contribute to alcohol drinking in animals and humans. Our previous studies demonstrated that blocking α1 -adrenergic receptors with the antagonist, prazosin, decreased alcohol drinking in rats under various conditions. As noradrenergic

Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol.

Canan Akyüz et al.

Pediatric blood & cancer, 61(5), 931-932 (2013-11-23)

Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year-old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with

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Global Trade Item Number

SKU	GTIN
1576005-200MG	04061838743435

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