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Cefotaxime sodium

Name: Cefotaxime sodium
Brand: USP

United States Pharmacopeia (USP) Reference Standard

Synonym(s):

Cefotaxime sodium salt, Cefotaxim sodium salt

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆N₅NaO₇S₂

CAS Number:

64485-93-4

Molecular Weight:

477.45

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329749255

MDL number:

MFCD00079073

Beilstein/REAXYS Number:

5711411

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Properties

grade

pharmaceutical primary standard

agency

USP

API family

cefotaxime

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

[Na+].[H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\c3csc(N)n3)C([O-])=O

InChI

1S/C16H17N5O7S2.Na/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8;/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26);/q;+1/p-1/b20-9-;/t10-,14-;/m1./s1

InChI key

AZZMGZXNTDTSME-JUZDKLSSSA-M

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Biochem/physiol Actions

Cefotaxim inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. As a result, bacteria lyse due to cell wall autolytic enzymes.

Mode of Action: Inhibits bacterial cell wall synthesis.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

Broad spectrum third generation cephalosporin antibiotic.

Sales restrictions may apply.

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1 of 1

This Item	C0685000	C7912	PHR2099
USP 1097909 Cefotaxime sodium	C0685000 Cefotaxime sodium	Sigma-Aldrich C7912 Cefotaxime sodium salt	Supelco PHR2099 Cefotaxime Sodium
manufacturer/tradename USP	manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename -
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade -	grade certified reference material, pharmaceutical secondary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) -	application(s) pharmaceutical small molecule
format neat	format neat	format -	format -
API family cefotaxime	API family cefotaxime	API family -	API family cefotaxime
storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C	storage temp. 2-8°C

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pictograms

GHS08

signalword

Danger

hcodes

H317,H334

pcodes

P261 - P280 - P284 - P304 + P340 - P342 + P311

Hazard Classifications

Resp. Sens. 1 - Skin Sens. 1

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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A dual-responsive pH-sensor and its potential as a universal probe for assays of pH-changing enzymes.

Hien Bao Dieu Thai et al.

The Analyst, 140(8), 2804-2809 (2015-02-28)

We described a dual turn-on probe sensitive to both acidity and basicity, which could be designed by connecting a fluorophore to a quencher via metal-ligand interaction. Atto488-labeled nitrilotriacetic acid and polyhistidine peptide were used as the fluorophore and the quencher

Review of cefotaxime sodium for surgical prophylaxis. A model for the evolution toward single-dose or short-course cost-effective regimens.

R N Jones

Diagnostic microbiology and infectious disease, 13(4), 317-327 (1990-07-01)

Cefotaxime is a parenteral broad-spectrum cephalosporin, used extensively worldwide for chemotherapy of serious infections. Since its release in 1979, cefotaxime has also been studied to minimize surgery-related infections and, more than any other new compound, has been used in a

The Escherichia coli phylogenetic group B2 with integrons prevails in childhood recurrent urinary tract infections.

Siiri Kõljalg et al.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 122(5), 452-458 (2013-09-17)

The aim of our study was to characterize the phylogenetic groups of Escherichia coli, antibiotic resistance, and containment of class 1 integrons in the first attack of pyelonephritis and in subsequent recurrences in young children. Altogether, 89 urine E. coli

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Global Trade Item Number

SKU	GTIN
1097909-500MG	04061838690388

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