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Superoxide dismutase–polyethylene glycol from bovine erythrocytes

Name: Superoxide dismutase–polyethylene glycol from bovine erythrocytes
Brand: SIGMA

lyophilized powder, ≥1,350 units/mg protein

Synonym(s):

PEG-SOD

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About This Item

UNSPSC Code:

12352204

NACRES:

NA.54

MDL number:

MFCD00678115

Specific activity:

≥1,350 units/mg protein

Pricing and availability is not currently available.

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Properties

form

lyophilized powder

Quality Segment

200, 400

specific activity

≥1,350 units/mg protein

mol wt

5000 Da

composition

Protein, ≥20% biuret

extent of labeling

≥10 mol PEG per mol protein

storage temp.

−20°C

Description

General description

Superoxide dismutase from bovine erythrocytes is a copper and zinc superoxide dismutase. Copper and zinc ions are coordinated by active site histidine residues. It has β-barrel structure.

Application

Superoxide dismutase-polyethylene glycol from bovine erythrocytes has been used:

in the incubation of lung slices for measurement of dihydroethidium (DHE) fluorescence in cultured bovine pulmonary artery endothelial cells[1]
as supplement in T cell culture to investigate its effect on cytokine production
in the preincubation of the carotid artery sections prior to DHE treatment

Biochem/physiol Actions

Superoxide dismutase-polyethylene glycol (SOD-PEG) is effective than SOD in scavenging free radicals in injuries. It reduces oxidative damage in ovarian follicles cell culture and during ovarian tissue transplantation. SOD-PEG is also effective in scavenging superoxide in mitochondrial abnormalities.

Packaging

Package size based on protein content

Physical form

Lyophilized powder containing PEG plus 5% citrate buffer salts

Preparation Note

Enzyme derived

Other Notes

Superoxide dismutase from bovine erythrocytes coupled to methoxy-polyethylene glycol, M.W. 5,000, through secondary amine linkage.

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This Item	S7446	S5395	574594
Sigma-Aldrich S9549 Superoxide dismutase–polyethylene glycol from bovine erythrocytes	Sigma-Aldrich S7446 Superoxide Dismutase from bovine erythrocytes	Sigma-Aldrich S5395 Superoxide Dismutase from bovine erythrocytes	Sigma-Aldrich 574594 Superoxide Dismutase, Bovine Erythrocytes
specific activity ≥1,350 units/mg protein	specific activity ≥4,500 units/mg protein	specific activity ≥3,000 units/mg protein	specific activity ≥3000 units/mg dry wt.
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized solid
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
mol wt 5000 Da	mol wt 32.5 kDa	mol wt 32.5 kDa	mol wt -
Quality Level 200, 400	Quality Level 200	Quality Level 200	Quality Level 100
extent of labeling ≥10 mol PEG per mol protein	extent of labeling -	extent of labeling -	extent of labeling -