S7076

SB 202190 monohydrochloride hydrate

≥98% (HPLC), solid, p38 MAP kinase inhibitor

• Synonym(s): 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate, 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate
• Empirical Formula (Hill Notation): C₂₀H₁₄FN₃O · HCl · xH₂O
• CAS Number: 350228-36-3
• Molecular Weight: 367.80 (anhydrous basis)
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824576
• NACRES: NA.77
• MDL number: MFCD17215958
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Properties

• Product Name: SB 202190 monohydrochloride hydrate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: ≥12 mg/mL
• originator: GlaxoSmithKline
• storage temp.: 2-8°C
• SMILES string: O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
• InChI: 1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2
• InChI key: CZZOICWZVYZUNP-UHFFFAOYSA-N

Description

Application

SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium and organoid culture medium It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.[1]

SB 202190 may be used to inhibit p38-mediated cell signaling.

Biochem/physiol Actions

SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.

SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.

SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.

Features and Benefits

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H315,H319,H335
• pcodes: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable