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Lipopolysaccharides from Salmonella enterica serotype typhimurium

Name: Lipopolysaccharides from <I>Salmonella enterica</I> serotype typhimurium
Brand: SIGMA

purified by trichloroacetic acid extraction

Synonym(s):

LPS

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About This Item

UNSPSC Code:

12352201

NACRES:

NA.25

MDL number:

MFCD00164404

Pricing and availability is not currently available.

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Properties

biological source

Salmonella enterica (Serotype typhimurium)

Quality Level

200

form

lyophilized powder

purified by

trichloroacetic acid extraction

impurities

1-10% Protein (Lowry)

color

white to faint yellow

solubility

water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow

shipped in

ambient

storage temp.

2-8°C

Description

General description

This product is TCA extracted from Salmonella typhimurium. The source strain is ATCC 7823. This LPS serotype has been used to induce NOS in rats and guinea pigs.

Application

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).

Biochem/physiol Actions

Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.

Preparation Note

The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 ^oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.

Other Notes

To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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This Item	L6511	L2262	L6143
Sigma-Aldrich L7261 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L6511 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L2262 Lipopolysaccharides from Salmonella enterica serotype typhimurium	Sigma-Aldrich L6143 Lipopolysaccharides from Salmonella enterica serotype typhimurium
biological source Salmonella enterica (Serotype typhimurium)	biological source Salmonella enterica (Serotype typhimurium)	biological source Salmonella enterica (Serotype typhimurium)	biological source Salmonella enterica (serotype typhimurium)
solubility water: 0.90-1.10 mg/mL, faintly hazy to hazy, colorless to faintly yellow	solubility water: 4.90-5.10 mg/mL, slightly hazy to turbid, colorless to faintly yellow	solubility water: 0.90-1.10 mg/mL, hazy to turbid, colorless to faintly yellow	solubility -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
color white to faint yellow	color white to faint yellow	color white to faint yellow	color -

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Immunomodulatory effects of heat stress and lipopolysaccharide on the bursal transcriptome in two distinct chicken lines.

Melissa S Monson et al.

BMC genomics, 19(1), 643-643 (2018-09-01)

Exposure to heat stress suppresses poultry immune responses, which can increase susceptibility to infectious diseases and, thereby, intensify the negative effects of heat on poultry welfare and performance. Identifying genes and pathways that are affected by high temperatures, especially heat-induced

Development of cell-mediated immunity to porcine circovirus type 2 (PCV2) in caesarean-derived, colostrum-deprived piglets.

Maria Fort et al.

Veterinary immunology and immunopathology, 129(1-2), 101-107 (2009-01-27)

The interaction between porcine circovirus type 2 (PCV2) and the pig immune system has been suggested to be a determinant event for the pathogenesis of postweaning multisystemic wasting syndrome (PMWS). To gain insight into the host immune mechanisms developed upon

Clinical and immunological evaluation after BCG-id vaccine in leprosy patients in a 5-year follow-up study.

Erika Muller Ramalho Zenha et al.

Journal of inflammation research, 5, 125-135 (2013-01-08)

The use of bacillus Calmette-Guérin (BCG) has long been considered a stimulus for immune reactivity in leprosy household contacts. Probably, the combination of multidrug therapy with BCG could facilitate the clearance of leprosy bacilli in the host, reduce relapse rates

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Global Trade Item Number

SKU	GTIN
L7261-10MG	04061833275269
L7261-25MG	04061833275276
L7261-100MG	04061833275252

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