F1177
Fluorescein hyaluronic acid
>95%, powder
Synonym(s):
Hyaluronic Acid Fluorescein Conjugate
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About This Item
Pricing and availability is not currently available.
Quality Segment
assay
>95%
form
powder
mol wt
~800,000 Da
color
orange
solubility
H2O: soluble 1 mg/mL
storage temp.
2-8°C
Application
Fluorescein hyaluronic acid has been used in the fluorescence imaging of hyaluronic acid (HA) and dextran surface coated filmsand patterned surfaces. It has also been used in confocal fluorescence microscopy to localize hyaluronic acid in collagen/HA composite gels .
Biochem/physiol Actions
Hyaluronan macromolecules (HAs) coupled to fluorescein amine is exploited to screen the hyaluronidase activity using fluorescence correlation spectroscopy (FCS) by measuring the quenching of fluorescein-labeled HA fragments.[1] It binds on cell surface of malignant mesothelioma derived from human tumors.
Used to bind on cell surface of malignant mesothelioma derived from human tumors.
Other Notes
From cock′s comb or by fermentation.
1 of 1
This Item | |||
|---|---|---|---|
| color orange | color orange | color yellow to orange | color - |
| solubility H2O: soluble 1 mg/mL | solubility water: 1 mg/mL | solubility H2O: soluble 25 mg/mL | solubility DMSO: soluble 1 mg/mL, chloroform: soluble 10 mg/mL, methanol: soluble 10 mg/mL |
| form powder | form solid | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| assay >95% | assay ≥95% (NMR) | assay - | assay ≥95% (HPLC) |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Rafal Fudala et al.
Journal of photochemistry and photobiology. B, Biology, 106, 69-73 (2011-11-16)
In this report we propose a lifetime-based sensing (LBS) for the detection of hyaluronidase (HA-ase). First, we heavily label hyaluronan macromolecules (HAs) with fluorescein amine. The fluorescein labeled HA (HA-Fl) has a weak fluorescence and short fluorescence lifetime due to
Human macrophage adhesion on polysaccharide patterned surfaces
Tsai IY, et al.
Soft Matter, 7(7), 3599-3606 (2011)
T Asplund et al.
Cancer research, 54(16), 4516-4523 (1994-08-15)
Hyaluronan-binding sites were demonstrated on the cell surface of three malignant mesothelioma cell lines derived from human tumors using either [3H]hyaluronan or fluorescein-tagged hyaluronan. No hyaluronan-binding activity was observed on normal human mesothelial cells. The absence of hyaluronan receptors on
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F1177-5MG | 04061833048122 |