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Spermine tetrahydrochloride

Name: Spermine tetrahydrochloride
Brand: SIGMA

From microbial,synthetic, ≥99.0% (AT), NMDA agonist/antagonist, powder or crystals

Synonym(s):

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₂₆N₄ · 4HCl

CAS Number:

306-67-2

Molecular Weight:

348.18

NACRES:

NA.77

PubChem Substance ID:

329769394

UNSPSC Code:

12352200

EC Number:

206-189-8

MDL number:

MFCD00012914

Beilstein/REAXYS Number:

3911771

Assay:

≥99.0% (AT)

Form:

powder or crystals

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Properties

Product Name

Spermine tetrahydrochloride, ≥99.0% (AT), powder or crystals

Quality Segment

300

biological source

microbial, synthetic

assay

≥99.0% (AT)

form

powder or crystals

mp

310-311 °C (dec.) (lit.)

solubility

H₂O: 0.1 g/mL, clear

storage temp.

room temp

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

Application

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

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This Item	S2876	85605	S1141
Sigma-Aldrich 85610 Spermine tetrahydrochloride	Sigma-Aldrich S2876 Spermine tetrahydrochloride	Sigma-Aldrich 85605 Spermine tetrahydrochloride	Sigma-Aldrich S1141 Spermine tetrahydrochloride
form powder or crystals	form powder or crystals	form powder	form solid
assay ≥99.0% (AT)	assay -	assay ≥99.5% (AT)	assay -
Quality Level 300	Quality Level 200	Quality Level 300	Quality Level 300
storage temp. room temp	storage temp. room temp	storage temp. -	storage temp. room temp
solubility H₂O: 0.1 g/mL, clear	solubility water, high purity: 100 mg/ml	solubility H₂O: 1 m at 20 °C, clear, colorless to almost colorless	solubility H₂O: soluble 100 mg/mL, clear, colorless to light yellow
mp 310-311 °C (dec.) (lit.)	mp 310-311 °C (dec.) (lit.)	mp 310-311 °C (dec.) (lit.)	mp 310-311 °C (dec.) (lit.)

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Global Trade Item Number

SKU	GTIN
870700P-10MG	04061835187010
C4282-100MG	04061833491935
C4282-25MG	04061833491959
C4282-10MG	04061833491942
870700P-25MG	04061835187027
85610-25G	04061833415993
85610-5G	04061833026724

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