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04573

Thiamine hydrochloride

tested according to Ph. Eur.

Synonym(s):

Thiamio hydrochloridum, Aneurine hydrochloride, Vitamin B1 hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C12H17ClN4OS · HCl
CAS Number:
67-03-8
Molecular Weight:
337.27
NACRES:
NA.26
PubChem Substance ID:
329747946
eCl@ss:
34058006
UNSPSC Code:
12352209
EC Number:
200-641-8
MDL number:
MFCD00012780
Beilstein/REAXYS Number:
3851771
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biological source

synthetic

Quality Level

200

agency

tested according to Ph. Eur.

assay

98.5-101.0% anhydrous basis

form

solid

mp

250 °C (dec.) (lit.)

solubility

alcohol: soluble 1 gm in 100 ml (95%), alcohol: soluble 1 gm in 315 ml (Absolute), glycerol: soluble 1 gm in 18 ml, water: soluble 1 g/mL, benzene: insoluble, chloroform: insoluble, diethyl ether: insoluble, hexane: insoluble, methanol: very soluble, propylene glycol: soluble

storage temp.

2-8°C

SMILES string

CC1=NC(N)=C(C[N+]2=CSC(CCO)=C2C)C=N1.Cl.[Cl-]

InChI

1S/C12H17N4OS.2ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);2*1H/q+1;;/p-1

InChI key

DPJRMOMPQZCRJU-UHFFFAOYSA-M

Application

Thiamine hydrochloride has been used as a keratin salts medium supplement for culturing log-phase fungus.[1] It has also been used as a supplement of VB medium the minimal medium of Vogel and Bonner.[2]

Biochem/physiol Actions

Thiamine hydrochloride is a cheap, non-toxic and efficient catalyst for the synthesis of amidoalkyl naphthols. It inhibits the production of shikonin derivatives by suspension cultures of Lithospermum erythrorhizon.[3] Additionally, thiamine hydrochloride addition to apple juice concentrates reduces its patulin content.[4]
Thiamine hydrochloride is a hydrochloride salt form of thiamine (Vitamin B1). It is crucial for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis.

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This Item
T4625PHR1037W332208
Thiamine hydrochloride tested according to Ph. Eur.

Sigma-Aldrich

04573

Thiamine hydrochloride

Thiamine hydrochloride reagent grade, ≥99% (HPLC)

Sigma-Aldrich

T4625

Thiamine hydrochloride

Thiamine hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1037

Thiamine hydrochloride

Thiamine hydrochloride ≥98%, FCC, FG

Sigma-Aldrich

W332208

Thiamine hydrochloride

Quality Level

200

Quality Level

200

Quality Level

300

Quality Level

300, 400

agency

tested according to Ph. Eur.

agency

-

agency

traceable to Ph. Eur. Y0000467, traceable to USP 1656002

agency

meets purity specifications of JECFA

mp

250 °C (dec.) (lit.)

mp

250 °C (dec.) (lit.)

mp

250 °C (dec.) (lit.)

mp

250 °C (dec.) (lit.)

form

solid

form

powder

form

solid

form

powder or crystals

solubility

alcohol: soluble 1 gm in 100 ml (95%), glycerol: soluble 1 gm in 18 ml, benzene: insoluble, diethyl ether: insoluble, methanol: very soluble, water: soluble 1 g/mL, hexane: insoluble, alcohol: soluble 1 gm in 315 ml (Absolute), propylene glycol: soluble, chloroform: insoluble

solubility

H2O: 50 mg/mL, clear, colorless

solubility

-

solubility

H2O: 1 g/10 mL, clear, colorless

assay

98.5-101.0% anhydrous basis

assay

≥99% (HPLC)

assay

-

assay

≥98%

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCP0977
BCCN6320
BCCM9897
BCCM2433
BCCL4289

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G Apodaca et al.
Infection and immunity, 57(10), 3081-3090 (1989-10-01)
Trichophyton rubrum is the most common dermatophyte of humans and normally colonizes the superficial layers of the epidermis (stratum corneum). Several proteinases with a possible role in the metabolism of host proteins have been purified from this fungus. The regulation
Thermodynamics of (solute+ solute) and (solute+ solvent) interactions of homologous series of amino acids with thiamine hydrochloride in aqueous medium at T=(305.15, 310.15, 315.15) K: A volumetric and acoustic approach
Kumar H and Behal I
The Journal of Chemical Thermodynamics, 102, 48-62 (2016)
G E Degnen et al.
Journal of bacteriology, 117(2), 477-487 (1974-02-01)
A mutator gene, mutD5, whose phenotype is conditional, has been identified in Escherichia coli. By P1 transduction it has been shown to lie at about 5.7 min on the chromosome, being co-transduced with proA and argF. In rich medium, streptomycin-
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Global Trade Item Number

SKUGTIN
W358401-1KG-K04061837800993
W358401-SAMPLE-K04061837536946
W358401-100G-K04061837800986
01984-250MG04061838611802
P8602-5G04061837330506
04573-50G-F04061838633767

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