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U0750

Uracil

≥99.0%, synthetic (organic), powder

Sinónimos:

2,4(1H,3H)-Pyrimidinedione, 2,4-Dihydroxypyrimidine, 2,4-Pyrimidinediol

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Fórmula empírica (notación de Hill):
C4H4N2O2
Número CAS:
Peso molecular:
112.09
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
200-621-9
MDL number:
Beilstein/REAXYS Number:
507828
Assay:
≥99.0%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan
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Nombre del producto

Uracil, ≥99.0%

biological source

synthetic (organic)

Quality Level

assay

≥99.0%

form

powder

mp

>300 °C (lit.)

solubility

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan

SMILES string

O=C1NC=CC(=O)N1

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChI key

ISAKRJDGNUQOIC-UHFFFAOYSA-N

General description

Uracil belongs to the pyrimidine nucleobase family. It is naturally occurring and is an important and active part of RNA.[1]

Application

Uracil has been used as:
  • a nucleotide standard to determine DNA methylation by high-performance liquid chromatography[2]
  • a component of synthetic define medium for culturing Saccharomyces cerevisiae and its strain
  • a component of the amino acid supplement to culture Bacillus sp[3]

Biochem/physiol Actions

Uracil and its derivatives play an integral part in medicinal chemistry for the synthesis of cancer, viral infections, autosomal recessive disorder, thyroid, and diabetic drugs.[1]

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Este artículo
U11286630Y0000764
Uracil

Millipore

6630

Uracil

biological source

synthetic (organic)

biological source

synthetic (organic)

biological source

-

biological source

-

Quality Level

300

Quality Level

200

Quality Level

100

Quality Level

-

form

powder

form

powder

form

crystalline solid

form

-

assay

≥99.0%

assay

≥99% (HPLC)

assay

≥99% (HPLC)

assay

-

solubility

1 M NaOH: 50 mg/mL, clear to hazy, colorless to faint yellow or tan

solubility

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

hot water: 1 mg/mL

solubility

-

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

-

mp

>300 °C (lit.)


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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Comparative metabolite profiling of wild type and thermo-tolerant mutant of Saccharomyces cerevisiae
Kim S, et al.
Process Biochemistry (Oxford, United Kingdom), 111, 62-68 (2021)
Deepthi Ramesh et al.
European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)
Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can
Sandra M Carvalho et al.
PloS one, 8(3), e58492-e58492 (2013-03-19)
Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains



Número de artículo de comercio global

SKUGTIN
U0750-25G04061835522316
U0750-1KG04061826746004
U0750-5G04061835559428
U0750-500G04061837403835
U0750-100G04061837403828

Questions

  1. Is their any information regarding the species and country of domicile the uracil is derived from?

    1 answer
    1. Please see the sample Certificate of Origin for this product. Please note that the Certificate of Origin is lot specific: https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COO/Q12/P2308-5MG0000143354.pdf

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