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P2191

Poly(D,L-lactide-co-glycolide)

lactide:glycolide (50:50), mol wt 30,000-60,000

Sinónimos:

LACTEL® B6010-2, PLGA

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Fórmula lineal:
[C3H4O2]x[C2H2O2]y
UNSPSC Code:
12352211
PubChem Substance ID:
NACRES:
NA.25
MDL number:
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feed ratio

lactide:glycolide (50:50)

Quality Level

mol wt

30,000-60,000

storage temp.

−20°C

SMILES string

OCC(O)=O.CC(O)C(O)=O

InChI key

XBBVURRQGJPTHH-UHFFFAOYSA-N

General description

Poly(D,L-lactide-co-glycolide) is a biodegradable and biocompatible polymer, which is used for drug delivery. It is used to treat rheumatoid arthritis, ulcerative colitis, Crohn′s disease, inflammatory lung diseases and ophthalmic inflammatory disorders. Poly(D,L-lactide-co-glycolide) functions as a potential cancer therapeutic target.

Application

Poly(D,L-lactide-co-glycolide) has been used to raise and sustain an increased lactate monomer level in the gel at a concentration relevant to dermal wounds.

Features and Benefits

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Physical form

Biocompatible, biodegradable polymer.

Legal Information

Lactel is a registered trademark of Evonik Corp

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Este artículo
430471P2066P1941
storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

feed ratio

lactide:glycolide (50:50)

feed ratio

lactide:glycolide 85:15

feed ratio

lactide:glycolide 65:35

feed ratio

lactide:glycolide (75:25)

mol wt

30,000-60,000

mol wt

Mw 50,000-75,000

mol wt

Mw 40,000-75,000

mol wt

66,000-107,000


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Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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Certificados de análisis (COA)

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Characterization of biodegradable poly (D, L-lactide-co-glycolide) polymers and microspheres
Hausberger AG and DeLuca PP
Journal of Pharmaceutical and Biomedical Analysis, 13(6), 747-760 (1995)
PLGA-based nanoparticles: an overview of biomedical applications
Danhier F, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 161(2), 505-522 (2012)
Habibun Nabi et al.
Parasitology research, 116(1), 359-370 (2016-10-28)
Toxoplasmosis is one of the most common zoonotic protozoal diseases. Recent advances in biotechnology have produced recombinant protein, which are immunogenic, and progress in nano-pharmaceutics has generated encapsulated protein in nanospheres, which are suitable for vaccine delivery. DNA was extracted



Número de artículo de comercio global

SKUGTIN
P2191-1G04061835513932
P2191-5G04061835513949

Questions

1–8 of 8 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. Is this product (P2191) ester terminated or acid terminated?

    1 answer
    1. It is ester terminated.

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  4. Please give me the detailed solubility profiling of this product with the solvent: Acetonitrile and Methanol

    1 answer
    1. This product is not tested for solubility. However, other sources report that this material is soluble in acetone at 5 wt%. Other solvents listed are dichloromethane, tetrahydrofuran, ethyl acetate, and chloroform. No rate is provided. This information has not been validated.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer
    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  6. What is the viscosity of Product P2191, Poly(D,L-lactide-co-glycolide)?

    1 answer
    1. The viscosity of this product is lot-specific and can be found in the Certificate of Analysis.

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  7. What is the glass transition temperature of Product P2191, Poly(D,L-lactide-co-glycolide)?

    1 answer
    1. The glass transition is 45-50°C; the melting point is amorphous.

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  8. Product P2191, Poly(D,L-lactide-co-glycolide), is a compound that is useful as a time-release agent in delivery systems such as herbicides, pesticides, and drugs.  What is the rate of degradation?

    1 answer
    1. The higher the lactic acid to glycolic acid ratio, the slower is the degradation rate of the polymer.  Molecular weight of the polymer is a contributing factor to the degradation; the lower the molecular weight, the faster the degradation rate of the polymer.

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