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A0200000

Acetylsalicylic acid

Name: Acetylsalicylic acid
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Aspirin

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Fórmula lineal:

2-(CH₃CO₂)C₆H₄CO₂H

Número CAS:

50-78-2

Peso molecular:

180.16

UNSPSC Code:

41116107

NACRES:

NA.24

PubChem Substance ID:

329770581

MDL number:

MFCD00002430

Beilstein/REAXYS Number:

779271

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Propiedades

grade

pharmaceutical primary standard

API family

aspirin

manufacturer/tradename

EDQM

mp

134-136 °C (lit.)

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CC(=O)Oc1ccccc1C(O)=O

InChI

1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)

InChI key

BSYNRYMUTXBXSQ-UHFFFAOYSA-N

Gene Information

human ... PTGS1(5742), PTGS2(5743)

Descripción

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Acetylsalicylic acid EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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Este artículo	Y0001460	PHR1003	1044006
A0200000 Acetylsalicylic acid	Y0001460 Acetylsalicylic acid for peak identification	Supelco PHR1003 Aspirin (Acetyl Salicylic Acid)	USP 1044006 Aspirin
manufacturer/tradename EDQM	manufacturer/tradename EDQM	manufacturer/tradename -	manufacturer/tradename USP
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade certified reference material, pharmaceutical secondary standard	grade pharmaceutical primary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
Gene Information human ... PTGS1(5742), PTGS2(5743)	Gene Information human ... PTGS1(5742), PTGS2(5743)	Gene Information human ... PTGS1(5742), PTGS2(5743)	Gene Information human ... PTGS1(5742), PTGS2(5743)
API family aspirin	API family aspirin	API family aspirin	API family aspirin

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pictograms

GHS07

signalword

Warning

Clase de almacenamiento

11 - Combustible Solids

wgk

WGK 1

flash_point_f

482.0 °F

flash_point_c

250 °C

hcodes

H302,H412

pcodes

P264 - P270 - P273 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3

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Lot/Batch Number

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Platelet response to low-dose enteric-coated aspirin in patients with stable cardiovascular disease.

Andrew O Maree et al.

Journal of the American College of Cardiology, 46(7), 1258-1263 (2005-10-04)

We investigated whether use of low-dose enteric-coated (EC) aspirin for secondary prevention of cardiovascular events has sufficient bioavailability to achieve complete platelet cyclooxygenase (COX) inhibition in all individuals. Aspirin reduces cardiovascular morbidity and mortality in patients with pre-existing vascular disease;

Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study.

Gregg W Stone et al.

Lancet (London, England), 382(9892), 614-623 (2013-07-31)

The relation between platelet reactivity and stent thrombosis, major bleeding, and other adverse events after coronary artery implantation of drug-eluting stents has been incompletely characterised. We aimed to determine the relation between platelet reactivity during dual therapy with aspirin and

Risk of upper gastrointestinal bleeding from different drug combinations.

Gwen M C Masclee et al.

Gastroenterology, 147(4), 784-792 (2014-06-18)

Concomitant use of nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin increases the risk of upper gastrointestinal bleeding (UGIB). Guidelines suggest avoiding certain drug combinations, yet little is known about the magnitude of their interactions. We estimated the risk of UGIB

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SKU	GTIN
A0200000	04061833327104

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