The exact loading is present on the batch specific certificate of analysis (COA). The specification sheet only shows the acceptance range for each batch, while the COA will show the testing results for a given batch.
8.55003
Rink Amide MBHA resin (100-200 mesh)
Novabiochem®
Sinónimos:
Rink Amide MBHA resin (100-200 mesh), 4-(2′,4′-Dimethoxyphenyl-Fmoc-aminomethyl)-phenoxyacetamido-norleucyl-MBHA resin (100-200 mesh)
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Servicio técnico
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Permítanos ayudarleQuality Level
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amine
storage temp.
2-30°C
SMILES string
N(C(c7c(cc(cc7)OC)OC)c4ccc(cc4)OCC(=O)NC(c6ccc(cc6)C)c5ccc(cc5)C)C(=O)OCC1c2c(cccc2)c3c1cccc3
InChI
1S/C47H44N2O6/c1-30-13-17-32(18-14-30)45(33-19-15-31(2)16-20-33)48-44(50)29-54-35-23-21-34(22-24-35)46(41-26-25-36(52-3)27-43(41)53-4)49-47(51)55-28-42-39-11-7-5-9-37(39)38-10-6-8-12-40(38)42/h5-27,42,45-46H,28-29H2,1-4H3,(H,48,50)(H,49,51)
InChI key
JDDWRLPTKIOUOF-UHFFFAOYSA-N
General description
This support comprises the modified Rink amide linker attached via norleucine to MBHA resin, and is an ideal tool for the Fmoc SPPS of peptide amides. Cleavage from this resin can be effected by a single step treatment with 95% TFA, providing peptide amides in high yields and purities.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Application
- Liquid chromatography-tandem mass spectrometry for forensic analysis: LSD-D₃ is utilized as an internal standard in the liquid chromatography-tandem mass spectrometry determination of LSD and its metabolites in forensic samples, enhancing accuracy and precision in the analytical results (Johansen and Jensen, 2005).
- Isotope dilution mass spectrometry in urine testing: Employed in the high-performance liquid chromatography-isotope dilution mass spectrometry (IDMS) method, LSD-D₃ serves as a crucial internal standard for the quantification of lysergide (LSD) in urine, aiding in precise and accurate drug testing (White et al., 1999).
- Automated extraction and LC/MS/MS confirmation: LSD-D₃ is used in the automated extraction of lysergic acid diethylamide from various biological matrices, followed by confirmation using LC/MS/MS. This application highlights its role in improving the efficiency and reliability of toxicological analyses (de Kanel et al., 1998).
Analysis Note
Colour (visual): white to light yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.90 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh.
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.90 mmol/g
TNBS-Test: passes test
Swelling Volume (in DMF): lot specific result
Swelling Volume (in CH₂Cl₂): lot specific result
Total swelling volume acc. Houben Weyl (in CH2Cl2): ≥ 5.2 ml/g
Total swelling volume acc. Houben Weyl (in DMF): ≥ 5.2 ml/g
The polymer matrix is copoly (styrene-1 % DVB), 100 -200 mesh.
Other Notes
Replaces: 01-64-0037
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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Este artículo | |||
|---|---|---|---|
| reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis | reaction suitability reaction type: Fmoc solid-phase peptide synthesis |
| product line Novabiochem® | product line Novabiochem® | product line Novabiochem® | product line Novabiochem® |
| functional group amine | functional group amine | functional group amine | functional group amine |
| Quality Level 400 | Quality Level 400 | Quality Level 400 | Quality Level 400 |
| application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis | application(s) peptide synthesis |
| storage temp. 2-30°C | storage temp. 2-30°C | storage temp. 2-30°C | storage temp. 2-30°C |
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| 8550030100 | 04027269182175 |
| 8550030025 | 04027269109219 |
| 8550030005 | 04027269109202 |
| 8550039010 | 04027269212797 |
| 8550035000 | 04027269689070 |
| 8550030250 | 04027269238759 |
| 8550030001 | 04027269109196 |
| 8550031000 | 04027269216726 |
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How can I determine the exact loading capacity of the MBHA Rink Amide resin, as a range for the loading capacity is given in the specification sheet instead of a one?
1 answer-
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Could you please clarify what is meant by "100-200 mesh"? Does it indicate that the substitution degree of the resin is between 0.1 mmol/g and 0.2 mmol/g?
1 answer-
he term "100-200 mesh" for Rink Amide MBHA resin refers to the particle size of the resin beads, not the substitution degree. The substitution degree for this resin is specified separately and is typically in the range of 0.40–0.90 mmol/g. Therefore, "100-200 mesh" does not indicate a substitution degree of 0.1–0.2 mmol/g.
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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