U4010
Urokinase from human kidney cells
lyophilized powder
Synonyme(s) :
u-Plasminogen activator
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A propos de cet article
Numéro CAS:
UNSPSC Code:
12352204
eCl@ss:
32160410
EC Number:
232-917-9
NACRES:
NA.54
MDL number:
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form
lyophilized powder
mol wt
heavy chain 30,400 Da, light chain 2000 Da
storage temp.
2-8°C
General description
Supplied as a lyophilized powder containing human albumin, mannitol and NaCl.
The principle active ingredient is the low molecular weight form of urokinase, and consists of an A chain of 2,000 daltons linked by a sulfhydyl bond to a B chain of 30,400 daltons.
Application
Urokinase from human kidney cells has been used as a component of digestion mix for three-dimensional fibrin culture. It has also been used in plasminogen activation assay.
Biochem/physiol Actions
Urokinase is a protease that cleaves plasminogen to form plasmin. It binds to cell surface receptors (uPAR) from which it regulates cell adhesion and migration during tissue remodeling and which also activate intracellular signaling pathways. Urokinase is composed of three domains: the amino terminal domain which is homologous to epidermal growth factor is attached through a central kringle domain to the protease domain in the carboxyl terminus.
Urokinase was shown to augment proliferation of renal tumor cells. [1]
Other Notes
Note: Higher activities are obtained when human plasminogen is used as substrate.
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Cet article | |||
|---|---|---|---|
| form lyophilized powder | form powder | form lyophilized | form lyophilized powder |
| mol wt heavy chain 30,400 Da, light chain 2000 Da | mol wt single-chain 14.3 kDa, Mr ~14600 | mol wt 60 kDa | mol wt heavy chain ~33 kDa, light chain ~5 kDa |
| Quality Level 200 | Quality Level 100 | Quality Level - | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. −20°C |
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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J C Kirchheimer et al.
Carcinogenesis, 9(11), 2121-2123 (1988-11-01)
Primary cultures of renal cell carcinomas and of the corresponding normal adjacent kidney tissue from 6 patients were analyzed for the effects of exogenously added urokinase-type plasminogen activator on cell proliferation as compared to the effects of tissue type plasminogen
Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin beta and fabricated fibrin matrices
Gavin KM, et al.
Adipocyte, 6(3), 234-249 (2017)
Benjamin J Buckley et al.
International journal of molecular sciences, 22(6) (2021-04-04)
The K+-sparing diuretic amiloride shows off-target anti-cancer effects in multiple rodent models. These effects arise from the inhibition of two distinct cancer targets: the trypsin-like serine protease urokinase-type plasminogen activator (uPA), a cell-surface mediator of matrix degradation and tumor cell
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| U4010-10KU | 04061837409530 |