Principaux documents

Voir toute la documentation

Passer à

I8250

3-Iodo-L-tyrosine

Name: 3-Iodo-<SC>L</SC>-tyrosine
Brand: SIGMA

Tyrosine hydroxylase inhibitor

Synonyme(s) :

3-Monoiodo-L-tyrosine

Se connecter pour consulter les tarifs organisationnels et contractuels.

Sélectionner une taille de conditionnement

Changer de vue

Conditionnement	Référence	Disponibilité	Prix

A propos de cet article

Formule linéaire :

IC₆H₃-4-(OH)CH₂CH(NH₂)CO₂H

Numéro CAS:

70-78-0

Poids moléculaire :

307.09

NACRES:

NA.32

PubChem Substance ID:

24278154

eCl@ss:

32160406

UNSPSC Code:

12352200

EC Number:

200-744-8

MDL number:

MFCD00002608

Beilstein/REAXYS Number:

2941266

Le tarif et la disponibilité ne sont pas disponibles actuellement.

Service technique

Besoin d'aide ? Notre équipe de scientifiques expérimentés est là pour vous.

Laissez-nous vous aider

Propriétés

Nom du produit

3-Iodo-L-tyrosine,

Quality Level

200

impurities

~5% tyrosine

mp

210 °C (dec.) (lit.)

solubility

dilute aqueous acid: soluble

storage temp.

−20°C

SMILES string

N[C@@H](Cc1ccc(O)c(I)c1)C(O)=O

InChI

1S/C9H10INO3/c10-6-3-5(1-2-8(6)12)4-7(11)9(13)14/h1-3,7,12H,4,11H2,(H,13,14)/t7-/m0/s1

InChI key

UQTZMGFTRHFAAM-ZETCQYMHSA-N

Gene Information

human ... TH(7054)

Description

General description

Iodotyrosine coupled with di-iodotyrosine results in the synthesis of 3,5,3′-tri-iodothyronine (T3) or 3,3′,5′-tri-iodothyronine (rT3).

Application

3-Iodo-L-tyrosine has been used as an inhibitor for tyrosine hydroxylase enzyme in Drosophila and silkworm pupae.

Biochem/physiol Actions

3-iodotyrosine (3-IY) inhibits tyrosine hydroxylase that catalyzes levodopa (L-DOPA) formation from tyrosine. Iodotyrosine deiodinase enzyme deficiency leads to elevated levels of 3-IY in serum and urine in severe hypothyroidism and goiter.

TH (tyrosine 3-hydroxylase) is responsible for catalyzing the first step of the noradrenergic biosynthesis pathway.[1][2] Mutations in TH are associated with tyrosine hydroxylase deficiency, leading to conditions such as infantile parkinsonism and DOPA (dopamine)-responsive dystonia as well as encephalopathy with perinatal onset.[3]

Tyrosine hydroxylase inhibitor.

Comparer avec des articles similaires

Voir la comparaison complète

Montrer les différences

1 of 1

Cet article	T5516	T6397	489859
Sigma-Aldrich I8250 3-Iodo-L-tyrosine	Sigma-Aldrich T5516 3,3′,5-Triiodo-L-thyronine sodium salt	Sigma-Aldrich T6397 3,3′,5-Triiodo-L-thyronine sodium salt	Sigma-Aldrich 489859 L-Tyrosine-3-¹³C
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
impurities ~5% tyrosine	impurities -	impurities -	impurities -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. -
Gene Information human ... TH(7054)	Gene Information human ... THRA(7067), THRB(7068) rat ... Thra(81812), Thrb(24831)	Gene Information human ... THRA(7067), THRB(7068) rat ... Thra(81812), Thrb(24831)	Gene Information -
solubility dilute aqueous acid: soluble	solubility -	solubility ethanol/1 M HCl (4:1): 10 mg/mL, clear, colorless to yellow	solubility -
mp 210 °C (dec.) (lit.)	mp -	mp -	mp >300 °C (dec.) (lit.)

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Faites votre choix parmi les versions les plus récentes :

Certificats d'analyse (COA)

Lot/Batch Number

Vous ne trouvez pas la bonne version ?

Si vous avez besoin d'une version particulière, vous pouvez rechercher un certificat spécifique par le numéro de lot.

Rechercher un(e) COA

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Tyrosine hydroxylase TH01 9.3 allele in the occurrence of sudden infant death syndrome in Swiss Caucasians.

Jacqueline Studer et al.

Journal of forensic sciences, 59(6), 1650-1653 (2014-07-01)

Catecholamines, especially noradrenalin, are essential in the control of respiration and arousal. Thus, an impaired production of these neurotransmitters may contribute to the occurrence of sudden infant death syndrome (SIDS). The first step of the noradrenergic synthesis pathway is catalyzed

Influence of dopamine on GABA release in striatum: evidence for D1-D2 interactions and non-synaptic influences.

L G Harsing et al.

Neuroscience, 77(2), 419-429 (1997-03-01)

Striatal slices from the rat were preincubated with [3H]GABA and superfused in the presence of nipecotic acid and aminooxyacetic acid, inhibitors of high-affinity GABA transport and GABA aminotransferase, respectively. GABA efflux was estimated by monitoring tritium efflux, 98% of which

Effects of 3-iodo-L-tyrosine, a tyrosine hydroxylase inhibitor, on eye pigmentation and biogenic amines in the planarian, Dugesia dorotocephala.

D K Ness et al.

Fundamental and applied toxicology : official journal of the Society of Toxicology, 30(2), 153-161 (1996-04-01)

Planarians (Dugesia dorotocephala) were evaluated as bioassay organisms to detect inhibition of tyrosine hydroxylase, the rate-limiting enzyme in the synthesis of catecholamines. Thirty planaria per dose were exposed to 0 (control), 0.001, 0.01, 0.1, or 1 mM 3-iodo-L-tyrosine (monoiodotyrosine or

Afficher tous les articles scientifiques apparentés

Numéro d'article de commerce international

Référence	GTIN
I8250-1G	04061833858493
I8250-25G	04061833858509
I8250-5G	04061833621110

Questions

Reviews

No rating value