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C0378
Chloramphénicol
≥98% (HPLC)
Synonyme(s) :
D-(−)-thréo-2,2-dichloro-N-[β-hydroxy-α-(hydroxyméthyl)-β-(4-nitrophényl)éthyl]acétamide, D-(−)-threo-2-dichloroacétamido-1-(4-nitrophényl)-1,3-propanediol, D-threo-2,2-dichloro-N-[β-hydroxy-α-(hydroxyméthyl)-4-nitrophenéthyl]acétamide, Chloromycétine
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| Conditionnement | Référence | Disponibilité | Prix |
|---|
A propos de cet article
Quality Level
assay
≥98% (HPLC)
form
powder or crystals
pKa
5.5
mp
149-153 °C (lit.)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma
mode of action
protein synthesis | interferes
storage temp.
room temp
SMILES string
OC[C@@H](NC(=O)C(Cl)Cl)[C@H](O)c1ccc(cc1)[N+]([O-])=O
InChI
1S/C11H12Cl2N2O5/c12-10(13)11(18)14-8(5-16)9(17)6-1-3-7(4-2-6)15(19)20/h1-4,8-10,16-17H,5H2,(H,14,18)/t8-,9-/m1/s1
InChI key
WIIZWVCIJKGZOK-RKDXNWHRSA-N
Gene Information
human ... CYP1A2(1544)
General description
Application
Le chloramphénicol a été utilisé comme antibiotique bactériostatique non puissant. Il a permis de sélectionner/faire croître des cellules bactériennes positives.
Biochem/physiol Actions
Mode de résistance : La chloramphénicol acétyltransférase acétyle, et donc, inactive le produit.
Spectre antimicrobien : Il s'agit d'un antibiotique à large spectre actif sur les bactéries à Gram positif et les bactéries à Gram négatif principalement destiné à un usage ophtalmologique et vétérinaire.
Preparation Note
Other Notes
Disclaimer
1 of 1
Cet article | |||
|---|---|---|---|
| mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action protein synthesis | interferes | mode of action - |
| antibiotic activity spectrum Gram-negative bacteria, mycobacteria, Gram-positive bacteria, mycoplasma | antibiotic activity spectrum viruses | antibiotic activity spectrum Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma | antibiotic activity spectrum - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level - |
| assay ≥98% (HPLC) | assay 97.0-103.0% | assay - | assay - |
| form powder or crystals | form crystalline | form powder | form - |
| storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. - |
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signalword
Danger
hcodes
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Repr. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Contenu apparenté
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| C0378-1KG | 04061835543045 |
| C0378-5G | 04061835543076 |
| C0378-25G | 04061835543052 |
| C0378-100G | 04061835543038 |
| C0378-500G | 04061835543069 |
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How can I determine the shelf life / expiration / retest date of this product?
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Was the pKa determined experimentally, or is it based on data from the literature? If the value is from the literature, please provide the source.
1 answer-
The value comes from literature. Two references that cite this value are:
Georgeta-Simona Stan, Irinel Adriana Badea, Hassan Y. Aboul-Enein, HPLC Method for Quantification of Five Compounds in a Parenteral Form Used in Treatment of Companion Animals, Journal of Chromatographic Science, Volume 54, Issue 9, 17 October 2016, Pages 1567–1572, https://doi.org/10.1093/chromsci/bmw105
Engesland, A., Škalko-Basnet, N., & Flaten, G. E. (2016). In vitro models to estimate drug penetration through the compromised stratum corneum barrier. Drug Development and Industrial Pharmacy, 42(11), 1742–1751. https://doi.org/10.3109/03639045.2016.1171334
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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