01810

Cycloheximide

≥95% (HPLC)

• Synonyme(s) : 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A
• Formule empirique (notation de Hill) : C₁₅H₂₃NO₄
• Numéro CAS: 66-81-9
• Poids moléculaire : 281.35
• PubChem Substance ID: 329747360
• UNSPSC Code: 51102829
• NACRES: NA.85
• EC Number: 200-636-0
• MDL number: MFCD00082346
• Beilstein/REAXYS Number: 88868

Propriétés

• biological source: microbial
• Quality Segment: 200
• assay: ≥95% (HPLC)
• form: powder or crystals
• color: white to light beige
• antibiotic activity spectrum: fungi, yeast
• mode of action: protein synthesis | interferes
• SMILES string: N1C(=O)CC(CC1=O)C[C@@H](O)[C@@H]2C[C@H](C[C@@H](C2=O)C)C
• InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1
• InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N
• Gene Information: human ... FKBP1A(2280), PIN1(5300)

Description

Application

Cyclohexamide (CHX) is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins, super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors. It has been shown to selectively clear macrophages in atherosclerotic plaques,[1] activate cumulus-free equine oocytes,[2] and to have neuroprotective properties.[3]

Biochem/physiol Actions

Cyclohexamide inhibits protein biosynthesis in eukaryotic cells by binding with the 80S ribosome.[4]

Cycloheximide (CHX) is an antibiotic produced by Strptomyces sp.. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Packaging

1G, 5G

Other Notes

Conditions for safe storage, including any incompatibilities. Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Informations sur la sécurité

• pictograms: GHS06,GHS08,GHS09
• signalword: Danger
• hcodes: H300,H341,H360D,H411
• pcodes: P202 - P264 - P273 - P280 - P301 + P310 - P391
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B
• Classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges