27602

Caféine

anhydrous, tested according to Ph. Eur.

• Synonyme(s) : 1,3,7-triméthylxanthine
• Formule empirique (notation de Hill) : C₈H₁₀N₄O₂
• Numéro CAS: 58-08-2
• Poids moléculaire : 194.19
• UNSPSC Code: 12352210
• NACRES: NA.21
• PubChem Substance ID: 329753004
• EC Number: 200-362-1
• Beilstein/REAXYS Number: 17705
• MDL number: MFCD00005758
• Grade: anhydrous
• Agency: tested according to Ph. Eur.

Propriétés

• grade: anhydrous
• Quality Segment: 100
• agency: tested according to Ph. Eur.
• form: powder
• mp: 234-236.5 °C (lit.)
• solubility: H₂O: soluble 18.7 g/L at 16 °C
• application(s): environmental
• SMILES string: CN1C(=O)N(C)c2ncn(C)c2C1=O
• InChI: 1S/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3
• InChI key: RYYVLZVUVIJVGH-UHFFFAOYSA-N
• Gene Information: human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), PDE4B(5142) ; mouse ... Adora2b(11541) ; rat ... Adora1(29290), Adora2a(25369)

Description

Application

Caffeine has been used as a radiosensitizing agent utilized for studying its impact in inhibiting the catalytic activity of ATM and ATR Kinase.[1] CTGF is an important modulator protein of fibrogenic TGF-β. Hence, this product has also been used for examining the caffeine-dependent regulation of CTGF expression in rat hepatocytes.[2]

Biochem/physiol Actions

Caffeine is a central nervous system stimulant, adenosine receptor antagonist as well as adenosine 3′,5′-cyclic monophosphate (cAMP) phosphodiesterase inhibitor. It stimulates the sarcoplasmic reticulum (SR) Ca²⁺-release channel which facilitates the excitation-contraction coupling in cardiac muscle.[3] It has also been reported to affect cellular calcium levels, releasing calcium from intracellular stores. Caffeine overrides the cell cycle effects of various chemicals such as protease inhibitors, preventing apoptosis; and it has been shown to inhibit cellular DNA repair mechanisms.[4]

Informations sur la sécurité

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe de stockage: 11 - Combustible Solids
• wgk: WGK 1
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• flash_point_f: Not applicable
• flash_point_c: Not applicable