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8.07491

Poly(éthylène glycol)

greener alternative

6000, for synthesis

Synonyme(s) :

PEG

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A propos de cet article

Formule linéaire :
H(OCH2CH2)nOH
Numéro CAS:
25322-68-3
NACRES:
NA.22
EC Index Number:
500-038-2
UNSPSC Code:
13111021
MDL number:
MFCD00081839
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vapor pressure

<0.01 hPa ( 20 °C)

Quality Segment

200

form

solid

autoignition temp.

420 °C

potency

28000 mg/kg LD50, oral (Rat), >20000 mg/kg LD50, skin (Rabbit)

greener alternative product characteristics

Safer Solvents and Auxiliaries
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sustainability

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pH

5-7 (20 °C, 100 g/L in H2O)

mp

58-63 °C

transition temp

flash point 270 °C

density

1.2 g/cm3 at 20 °C

greener alternative category

Aligned

storage temp.

2-30°C

SMILES string

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

InChI key

LYCAIKOWRPUZTN-UHFFFAOYSA-N

General description

Polyethylene glycol (PEG) is a synthetic, hydrophilic, biocompatible polymer that has a wide range of uses in PEGylation, surface conjugation, nanoparticle coating, and crosslinking for hydrogels, etc. PEGs are made by polymerizing ethylene oxide via a ring-opening reaction to produce a wide range of molecular weights and molecular weight distributions (polydispersity).
We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Green Chemistry. Polyethylene glycol (PEG) is an eco-friendly, biodegradable polymer widely used in pharmaceuticals and cosmetics. Its non-toxic nature and versatility make it a sustainable choice, derived from renewable resources, contributing to greener product formulations. Click here for more information.

Application

Polyethylene glycol 6000 is a non-ionic surfactant that can be used as a structure-directing agent to prepare mesoporous γ-Al2O3. PEG 6000 induced the formation of the lamellate structure morphology of boehmite nanoparticles with improved textural properties such as high surface area, larger pore volume, and pore size. It is also used in drug formulations to enhance the dissolution rate of the poorly water-soluble drug molecule.[1][2] PEG-6000 can also be used in the purification of nucleic acids via the selective precipitation method. This approach is economically cost-effective and faster than the commonly employed chromatographic purification method.[3]

Analysis Note

Melting range (lower value): ≥ 59 °C
Melting range (upper value): ≤ 64 °C
Hydroxyl value: 16 - 23
Average molecular mass: 5000 - 7000
Identity (IR): passes test

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Cet article
8.074868.190158.07488
Polyethylene glycol 6000, for synthesis

Sigma-Aldrich

8.07491

Polyethylene glycol

Polyethylene glycol 600, for synthesis

Sigma-Aldrich

8.07486

Polyethylene glycol

Polyethylene glycol 3000, for synthesis

Sigma-Aldrich

8.19015

Polyethylene glycol

Polyethylene glycol 1000, for synthesis

Sigma-Aldrich

8.07488

Polyethylene glycol

form

solid

form

liquid

form

liquid

form

liquid

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

2-30°C

storage temp.

no temp limit

storage temp.

2-30°C

storage temp.

2-30°C

mp

58-63 °C

mp

17-22 °C

mp

55-58 °C

mp

33-40 °C

density

1.2 g/cm3 at 20 °C

density

1.13 g/cm3 at 20 °C

density

1.21 g/cm3 at 20 °C

density

1.2 g/cm3 at 20 °C

potency

28000 mg/kg LD50, oral (Rat), >20000 mg/kg LD50, skin (Rabbit)

potency

28000 mg/kg LD50, oral (Rat), >20000 mg/kg LD50, skin (Rabbit)

potency

28000 mg/kg LD50, oral (Rat), >20000 mg/kg LD50, skin (Rabbit)

potency

28000 mg/kg LD50, oral (Rat), >20000 mg/kg LD50, skin (Rabbit)

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Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

281.5 °F - closed cup

flash_point_c

138.6 °C - closed cup

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

A facile rout to synthesis lamellate structure mesoporous alumina using polyethylene glycol 6000 (PEG, molecular weight= 6000) as structure directing agent
Su Ai-ping, et al.
Microporous and Mesoporous Materials : The Official Journal of the International Zeolite Association, 159, 36-41 (2012)
S Verheyen et al.
International journal of pharmaceutics, 249(1-2), 45-58 (2002-11-16)
Solid dispersion literature, describing the mechanism of dissolution of drug-polyethylene glycol dispersions, still shows some gaps; (A). only few studies include experiments evaluating solid solution formation and the particle size of the drug in the dispersion particles, two factors that
S Biswal et al.
AAPS PharmSciTech, 9(2), 563-570 (2008-05-07)
The aim of the present study was to enhance the dissolution rate of gliclazide using its solid dispersions (SDs) with polyethylene glycol (PEG) 6000. The phase solubility behavior of gliclazide in presence of various concentrations of PEG 6000 in 0.1
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Numéro d'article de commerce international

RéférenceGTIN
807491000004022536395951
807491100004022536395968
807491500004022536395975
807491905104022536864716
807491905004022536395999

Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Is it possible to use the product Polyethylene glycol 6000 (8074911000) to soften seed coats to aid in germination?

    1 answer

    1. The information from Jelitto Perennial Seeds suggests that for hard-shelled seeds, mechanical damaging of the shell or treatment with a softener such as Polyethylene glycol 6000 (PEG 6000) can be helpful for quicker swelling. However, there is no specific mention of product number 807491 in particular for this purpose.

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