S8534

Sarsasapogenin

≥98%

• Synonym(s): (25S)-Spirostan-3β-ol, Parigenin
• Empirical Formula (Hill Notation): C₂₇H₄₄O₃
• CAS Number: 126-19-2
• Molecular Weight: 416.64
• NACRES: NA.25
• PubChem Substance ID: 24899798
• UNSPSC Code: 12352200
• EC Number: 204-776-3
• MDL number: MFCD00270414

Properties

• Quality Level: 200
• assay: ≥98%
• application(s): metabolomics; vitamins, nutraceuticals, and natural products
• SMILES string: C[C@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC[C@@H]6C[C@@H](O)CC[C@]6(C)[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C
• InChI: 1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17-,18+,19-,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1
• InChI key: GMBQZIIUCVWOCD-WWASVFFGSA-N

Description

General description

Sarsasapogenin also known as Sarsagenin or Parigenin, is a steroidal saponin and is the main constituent of Anemarrhena asphodeloides Bunge.[1]

Application

Sarsasapogenin has been used as a synthetic saponin treatment to U-2 OS cells to test its effects in reducing osteosarcoma cell viability and down-regulating YAP and TAZ proteins.[2]

Biochem/physiol Actions

Sarsasapogenin is a well-known multi-target directed ligand (MTDL) for Alzheimer′s disease.[3] It elicits anti-inflammatory, antioxidant, anti-arthritis, anti-asthma, anti-amyloidogenic, neuroprotective, anti-depressant, and anti-cancer properties.[1][3][4] SAR also improves learning and memory ability, loss of neurons in type-1 diabetic rats and protects against diabetic encephalopathy.[1] It is also a therapeutic target for treating ulcerative colitis (UC).[4] SAR as an anti-inflammatory agent improves insulin resistance and adipose tissue inflammation in high-fat diet (HFD)-fed mice.[5]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)