P9405

O-Phospho-L-tyrosine

≥95.0% (HPLC)

• Synonym(s): L-3-(4-Hydroxyphenyl)alanine 4′-phosphate, L-Tyrosine-O-phosphate
• Empirical Formula (Hill Notation): C₉H₁₂NO₆P
• CAS Number: 21820-51-9
• Molecular Weight: 261.17
• UNSPSC Code: 12352209
• eCl@ss: 32160406
• PubChem Substance ID: 24899034
• NACRES: NA.26
• Beilstein/REAXYS Number: 3150815
• MDL number: MFCD00002603

Properties

• Product Name: O-Phospho-L-tyrosine,
• assay: ≥95.0% (HPLC)
• Quality Segment: 100
• form: powder
• color: white to off-white
• mp: 225 °C
• application(s): cell analysis
• storage temp.: −20°C
• SMILES string: N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(O)=O
• InChI: 1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1
• InChI key: DCWXELXMIBXGTH-QMMMGPOBSA-N

Description

Application

O-Phospho-L-tyrosine has been used:

• as a diluent of anti-phosphotyrosine antibody to study sperm capacitation[1]
• as an amino acid standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis[2]
• as an amino acid standard in two-dimensional thin-layer electrophoresis system to analyze phosphoamino acids on the phosphorylated starch phosphorylase (L-SP)[3]

Biochem/physiol Actions

Phosphotyrosine acts as a docking site in protein regulation by stimulating interaction between tyrosine-phosphorylated proteins and phosphotyrosine domains of other proteins.[4]

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)