N7261

Nortriptyline hydrochloride

≥98% (HPLC), norepinephrine and serotonin inhibitor, powder

• Synonym(s): 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine hydrochloride, Desmethylamitriptyline hydrochloride
• Empirical Formula (Hill Notation): C₁₉H₂₁N · HCl
• CAS Number: 894-71-3
• Molecular Weight: 299.84
• NACRES: NA.77
• PubChem Substance ID: 24278107
• UNSPSC Code: 41116107
• EC Number: 212-973-0
• MDL number: MFCD00058024
• Assay: ≥98% (HPLC)
• Form: powder
• Quality level: 200

Properties

• Product Name: Nortriptyline hydrochloride, ≥98% (HPLC), powder
• Quality Level: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white to off-white
• solubility: ethanol: 100 mg/mL, H₂O: soluble
• originator: Eli Lilly
• SMILES string: Cl.CNCC\C=C1\c2ccccc2CCc3ccccc13
• InChI: 1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-11,20H,6,12-14H2,1H3;1H
• InChI key: SHAYBENGXDALFF-UHFFFAOYSA-N
• Gene Information: human ... HTR2A(3356), HTR2B(3357), HTR2C(3358), SLC6A2(6530), SLC6A4(6532)

Description

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (K_i = 3.4 nM) than the serotonin transporter (K_i = 161 nM). 5-HT₂ serotonin receptor antagonist.

Features and Benefits

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves