M2939

Methyl arachidonyl fluorophosphonate

≥98%, calcium-dependent and calcium-independent cytosolic phospholipase A2 inhibitor, methyl acetate solution (10 mg/mL)

• Synonym(s): MAPF, Phosphonofluoridic acid, methyl-5Z,8Z,11Z,14Z-eicosatetraenyl ester
• Empirical Formula (Hill Notation): C₂₁H₃₆FO₂P
• CAS Number: 188404-10-6
• Molecular Weight: 370.48
• NACRES: NA.77
• PubChem Substance ID: 329817956
• UNSPSC Code: 41106300
• EC Number: 201-185-2
• MDL number: MFCD03095722
• Assay: ≥98%
• Form: methyl acetate solution (10 mg/mL)

Properties

• Product Name: Methyl arachidonyl fluorophosphonate, ≥98%, methyl acetate solution (10 mg/mL)
• Quality Segment: 200
• assay: ≥98%
• form: methyl acetate solution (10 mg/mL)
• shipped in: dry ice
• storage temp.: −70°C
• SMILES string: CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCCP(F)(=O)OC
• InChI: 1S/C21H36FO2P/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-25(22,23)24-2/h7-8,10-11,13-14,16-17H,3-6,9,12,15,18-21H2,1-2H3/b8-7-,11-10-,14-13-,17-16-
• InChI key: KWKZCGMJGHHOKJ-ZKWNWVNESA-N

Description

Biochem/physiol Actions

MAFP is a selective, irreversible inhibitor of both calcium-dependent and calcium-independent cytosolic phospholipase A₂, but not secretory phospholipase A₂. MAFP is also a potent acetylcholinesterase inhibitor.

Preparation Note

To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.

Disclaimer

Supply conditions do not apply to the regions and states of Brazil: North, Northeast, Mato Grosso do Sul, Mato Grosso, and Rio Grande do Sul.

Safety Information

• pictograms: GHS02,GHS07
• signalword: Danger
• hcodes: H225,H319,H336
• pcodes: P210 - P233 - P240 - P241 - P242 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
• target_organs: Central nervous system
• supp_hazards: EUH066
• Storage Class: 3 - Flammable liquids
• wgk: WGK 2
• flash_point_f: 3.2 °F - closed cup
• flash_point_c: -16 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter