Works excellent in the animal model.................
L3755
Lipopolysaccharides from Escherichia coli O26:B6
purified by trichloroacetic acid extraction
Lipopolysaccharides from Escherichia coli O26:B6
Synonym(s):
LPS
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About This Item
Pricing and availability is not currently available.
biological source
Escherichia coli (O26:B6)
Quality Level
form
lyophilized powder
purified by
trichloroacetic acid extraction
impurities
1-10% Protein (Lowry)
color
white to yellow
solubility
water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
This product is TCA extracted from E. coli serotype O26:B6. The source strain is ATCC 12795. LPS from serotype 026:B6 is the only LPS from E. coli which exhibits short chain-length behavior on SDS-PAGE. The short chain-length of this LPS is closer to that of the mutant rough strain LPS.
Application
Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Biochem/physiol Actions
Lipopolysaccharides (LPS) are localized in the outer layer of the membrane and are, in noncapsulated strains, exposed on the cell surface. They contribute to the integrity of the outer membrane, and protect the cell against the action of bile salts and lipophilic antibiotics.
Preparation Note
The product is soluble in water (5 mg/ml) or cell culture medium (1 mg/ml) yielding a hazy, faint yellow solution. A more concentrated, though still hazy, solution (20 mg/ml) has been achieved in aqueous saline after vortexing and warming to 70-80 oC. Lipopolysaccharides are molecules that form micelles in every solvent. Hazy solutions are observed in water and phosphate buffered saline. Organic solvents do not give clearer solutions. Methanol yields a turbid suspension with floaters, while water yields a homogeneously hazy solution.
Other Notes
To gain a comprehensive understanding of our extensive range of Lipopolysaccharides for your research, we encourage you to visit our Carbohydrates Category page.
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This Item | |||
|---|---|---|---|
| biological source Escherichia coli (O26:B6) | biological source Escherichia coli (O55:B5) | biological source Escherichia coli (O26:B6) | biological source Escherichia coli (O26:B6) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| solubility water: soluble | solubility water: soluble | solubility water: 4.90-5.10 mg/mL, cloudy to hazy, colorless to faintly yellow | solubility water: soluble |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| impurities 1-10% Protein (Lowry) | impurities 1-10% Protein (Lowry) | impurities <5% Protein | impurities <3% Protein (Lowry) |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Rupali Sharma et al.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 71, 94-104 (2018-08-31)
Puberty is a critical developmental period that is characterized by significant brain development. Exposure to stress during this time can alter brain functioning setting the stage for long-lasting behavioural outcomes. The objective of this study was to investigate age and
Georg Stoecklin et al.
The Journal of biological chemistry, 283(17), 11689-11699 (2008-02-08)
Tristetraprolin (TTP) is an RNA-binding protein required for the rapid degradation of mRNAs containing AU-rich elements. Targets regulated by TTP include the mRNAs encoding tumor necrosis factor-alpha, granulocyte-macrophage colony-stimulating factor, interleukin-2 (IL-2), and immediate early response 3. To identify novel
Guohui Cai et al.
Scientific reports, 6, 21097-21097 (2016-02-13)
Early life diet can critically program hypothalamic-pituitary-adrenal (HPA) axis function. We have previously shown rats that are overfed as neonates have exacerbated pro-inflammatory responses to immune challenge with lipopolysaccharide (LPS), in part by altering HPA axis responses, but how this
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L3755-500MG | 04061833952306 |
| L3755-100MG | 04061833952290 |