It is recommended that I7908 be reconstituted in 50mm Phosphate buffer, pH 7 containing 0.1 % BSA or HSA. Please see the link below the access the product datasheet for additional information:
https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/product/documents/427/488/i7908dat.pdf
I7908
IL-2 human
≥98% (SDS-PAGE and HPLC), recombinant, expressed in Pichia pastoris, lyophiilized powder, suitable for cell culture
Synonym(s):
IL-2, Interleukin-2, T-cell growth factor
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About This Item
Biological source:
human
Recombinant:
expressed in Pichia pastoris
Assay:
≥98% (SDS-PAGE and HPLC)
Form:
lyophilized powder
Mol wt:
predicted mol wt ~15 kDa
Impurities:
endotoxin, tested
Pricing and availability is not currently available.
Product Name
Interleukin-2 human, recombinant, expressed in Pichia pastoris, suitable for cell culture
biological source
human
Quality Segment
recombinant
expressed in Pichia pastoris
assay
≥98% (SDS-PAGE and HPLC)
form
lyophilized powder
mol wt
predicted mol wt ~15 kDa
packaging
pkg of 10KU
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Application
Interleukin-2 human has been used to assess changes in tumor necrosis factor receptor 1 (TNFR1). It has also been used in TNFR2 expression on Tregs.
Biochem/physiol Actions
Interleukin 2 (IL2) is a pro-inflammatory cytokine. It consists of three subunits, in which the β subunit is important for receptor mediated signaling. IL2 enhances the development of T regulatory cells and plays a crucial role in antitumor immunity.
Interleukin-2 (IL-2) is an immunomodulatory factor produced by certain subsets of T lymphocytes. This lymphokine promotes long term growth of activated T cells and related cell types. IL-2 plays a role in the activation and proliferation of NK cells, induces γ-interferon and B cell growth factor secretion, and modulates the expression of the IL-2 receptor.
Physical form
Lyophilized from a 0.2 μm filtered solution in 50 mM sodium phosphate buffer, pH 7.0, containing 0.1% human serum albumin per 0.1 mL of cytokine.
Analysis Note
The biological activity is tested in a cell proliferation assay using an IL-2 dependent murine cytotoxic T cell line, CTLL-2.
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This Item | |||
|---|---|---|---|
| biological source human | biological source mouse | biological source human | biological source human |
| technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable |
| assay ≥98% (SDS-PAGE and HPLC) | assay ≥97% (SDS-PAGE) | assay - | assay ≥97% (HPLC and SDS-PAGE) |
| recombinant expressed in Pichia pastoris | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
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Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Tenemos IL-2 expresado en Pichia Pastoris desde hace un tiempo con esta referencia (I7908) sin reconstituir. Hemos perdido el data sheet y no sabemos en qué solución debemos reconstituirlo. Contacte conmigo para resolver nuestra duda.
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