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Ethosuximide

Name: Ethosuximide
Brand: SIGMA

T-type calcium channel antagonist

Synonym(s):

2-Ethyl-2-methylsuccinimide

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About This Item

Empirical Formula (Hill Notation):

C₇H₁₁NO₂

CAS Number:

77-67-8

Molecular Weight:

141.17

NACRES:

NA.77

PubChem Substance ID:

24278423

UNSPSC Code:

12352111

EC Number:

201-048-7

MDL number:

MFCD00072123

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Properties

Product Name

Ethosuximide,

Quality Segment

100

solubility

ethanol: 100 mg/mL

SMILES string

O=C1NC(CC1(C)CC)=O

InChI

1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)

InChI key

HAPOVYFOVVWLRS-UHFFFAOYSA-N

Gene Information

human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Description

Application

Ethosuximide has been used:

to confirm its effect on spike wave discharges (SWD) in rats
to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item	PHR1413	E101	B016
Sigma-Aldrich E7138 Ethosuximide	Supelco PHR1413 Ethosuximide	Sigma-Aldrich E101 S-(−)-Eticlopride hydrochloride	Sigma-Aldrich B016 Benoxathian hydrochloride
Quality Level 100	Quality Level 300	Quality Level 100	Quality Level 100
solubility ethanol: 100 mg/mL	solubility -	solubility H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL	solubility H₂O: soluble (Aqueous solutions may be stored for several weeks at -20 °C.), ethanol: soluble, isopropanol: soluble
Gene Information human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)	Gene Information human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)	Gene Information human ... DRD2(1813)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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