The solubility has been tested at 10mg/mL in 0.1M Boric acid, resulting in a white haze.
C9801
Casein, N,N-dimethylated from bovine milk
essentially salt-free, lyophilized powder
Synonym(s):
N,N-dimethylcasein
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About This Item
Form:
essentially salt-free, lyophilized powder
Assay:
≥90% (colorimetric)
Biological source:
bovine milk
Pricing and availability is not currently available.
biological source
bovine milk
Quality Segment
assay
≥90% (colorimetric)
form
essentially salt-free, lyophilized powder
technique(s)
activity assay: suitable
storage temp.
−20°C
SMILES string
[P](=O)(OCC(NC(=O)C(NC(=O)C(N)Cc1ccccc1)CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(C(O)C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C
InChI
1S/C81H125N22O39P/c1-36(2)31-50(76(132)94-43(15-24-57(87)108)71(127)101-52(34-64(120)121)78(134)98-49(81(137)138)11-7-8-30-82)99-72(128)47(19-28-61(114)115)95-77(133)51(33-63(118)119)100-73(129)48(20-29-62(116)117)97-80(136)65(37(3)104)103-75(131)44(16-25-58(88)109)92-68(124)42(14-23-56(86)107)90-67(123)41(13-22-55(85)106)91-69(125)45(17-26-59(110)111)93-70(126)46(18-27-60(112)113)96-79(135)53(35-142-143(139,140)141)102-74(130)40(12-21-54(84)105)89-66(122)39(83)32-38-9-5-4-6-10-38/h4-6,9-10,36-37,39-53,65,104H,7-8,11-35,82-83H2,1-3H3,(H2,84,105)(H2,85,106)(H2,86,107)(H2,87,108)(H2,88,109)(H,89,122)(H,90,123)(H,91,125)(H,92,124)(H,93,126)(H,94,132)(H,95,133)(H,96,135)(H,97,136)(H,98,134)(H,99,128)(H,100,129)(H,101,127)(H,102,130)(H,103,131)(H,110,111)(H,112,113)(H,114,115)(H,116,117)(H,118,119)(H,120,121)(H,137,138)(H2,139,140,141)
InChI key
BECPQYXYKAMYBN-UHFFFAOYSA-N
Gene Information
bovine ... CSN1S1(282208), CSN1S2(282209), CSN2(281099), CSN3(281728)
General description
Casein is a milk protein, that is not expensive and nontoxic. highly stable. This phosphoproteins accounts for 80% of the total protein present in bovine milk. Casein is a member of one of the larger family of secretory calcium?binding phosphoproteins.
Application
Casein, N,N-dimethylated from bovine milk can be used in assays to detect and help determine the functional role of tissue transglutaminase (tTG) in disease. In particular, Casein, N,N-dimethylated has been used in the mechanic and kinetic analysis of tTG on protein substrates, which may be linked to neurodegenerative disease.
This preparation has less than 10% reactivity with 2,4,6-trinitrobenzenesulfonic acid (TNBS) compared to non-methylated casein.
Protease substrate that has been used to assay basilase[1] and a subtilisin analog that had been produced by site-directed mutagenesis.[2]
This preparation has less than 10% reactivity with 2,4,6-trinitrobenzenesulfonic acid (TNBS) compared to non-methylated casein.
Protease substrate that has been used to assay basilase[1] and a subtilisin analog that had been produced by site-directed mutagenesis.[2]
Casein, N,N-dimethylated from bovine milk has been used:
- in the determination of general proteolytic activity
- as a substrate to study the effect of dephosphorylation on the calcium-activated neutral proteases (CANP) proteolysis of paired helical filaments (PHF) II-τ
- in transglutaminase (TG) assay
Biochem/physiol Actions
Casein is highly preferred as a drug delivery vehicle. It possess antioxidant activity.
Preparation Note
Reductive methylation of C5890 by the method of Cabacungan, J.C., et al., Anal. Biochem., 124, 272 (1982).
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This Item | |||
|---|---|---|---|
| assay ≥90% (colorimetric) | assay - | assay ≥85% (biuret) | assay - |
| technique(s) activity assay: suitable | technique(s) activity assay: suitable, electrophoresis: suitable, immunocytochemistry: suitable | technique(s) - | technique(s) - |
| biological source bovine milk | biological source bovine milk | biological source bovine milk | biological source - |
| form essentially salt-free, lyophilized powder | form purified powder | form lyophilized powder | form - |
| storage temp. −20°C | storage temp. - | storage temp. 2-8°C | storage temp. - |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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What is Product C9801, N,N-dimethylated casein, soluble in?
1 answer-
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What is the purity of Product No. C9801, N,N-dimethylated casein?
1 answer-
This product is not sold by purity, but by the percent of N,N-methylation. It is required to be at least 90% methylated.
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What is the molecular weight of Product C9801, N,N-dimethylated casein?
1 answer-
Unfortunately, we have not determined the molecular weight. The molecular weight of casein is 26 kDa or less; the molecular weight of Product No. C9801 is expected to be a bit higher.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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