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N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride

Name: N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride
Brand: SIGMA

≥98% (TLC), solid, adrenergic neurotoxin

Synonym(s):

DSP-4, N-Ethyl-N-(2-chloroethyl)-2-bromobenzylamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₅BrClN · HCl

CAS Number:

40616-75-9

Molecular Weight:

313.06

NACRES:

NA.77

PubChem Substance ID:

24277753

UNSPSC Code:

12352116

MDL number:

MFCD00043241

Beilstein/REAXYS Number:

4020910

Assay:

≥98%

Form:

solid

Quality level:

200

Pricing and availability is not currently available.

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Properties

Product Name

N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride, ≥98%, solid

Quality Level

200

assay

≥98%

form

solid

color

white

solubility

H₂O: 48 mg/mL, 0.1 M NaOH: 7 mg/mL, ethanol: soluble

SMILES string

Cl[H].CCN(CCCl)Cc1ccccc1Br

InChI

1S/C11H15BrClN.ClH/c1-2-14(8-7-13)9-10-5-3-4-6-11(10)12;/h3-6H,2,7-9H2,1H3;1H

InChI key

NDDRNRRNYOULND-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Adrenergic neurotoxin that induces acute and relatively selective degeneration of both central and peripheral noradrenergic nerve terminals.

Preparation Note

Solutions in ethanol, water or 0.1 N NaOH should be freshly prepared.

Disclaimer

Hygroscopic.

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This Item	E101	B019	N151
Sigma-Aldrich C8417 N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride	Sigma-Aldrich E101 S-(−)-Eticlopride hydrochloride	Sigma-Aldrich B019 Phenoxybenzamine hydrochloride	Sigma-Aldrich N151 Nisoxetine hydrochloride
assay ≥98%	assay ≥98% (HPLC)	assay ≥97%	assay ≥98% (HPLC)
form solid	form powder	form powder	form solid
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
solubility H₂O: 48 mg/mL, ethanol: soluble, 0.1 M NaOH: 7 mg/mL	solubility H₂O: soluble >10 mg/mL, ethanol: soluble 2.6 mg/mL, 0.1 M HCl: soluble 7 mg/mL	solubility H₂O: slightly soluble, alcohol: soluble, propylene glycol: soluble	solubility H₂O: 20 mg/mL, ethanol: 50 mg/mL
color white	color off-white	color white	color white to beige

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000480594

0000458759

0000458788

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Increasing CNS noradrenaline reduces EAE severity.

Maria Vittoria Simonini et al.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 5(2), 252-259 (2009-12-04)

The endogenous neurotransmitter noradrenaline (NA) is known to exert potent anti-inflammatory effects in glial cells, as well as provide neuroprotection against excitatory and inflammatory stimuli. These properties raise the possibility that increasing levels of NA in the central nervous system

Role of coerulean noradrenergic neurones in general anaesthesia in rats.

T Kushikata et al.

British journal of anaesthesia, 107(6), 924-929 (2011-10-04)

Central noradrenergic neurones have a role in alertness, analgesia, and thermoregulation; these neurones are also involved in the mechanism of anaesthesia. Locus coeruleus neurones innervate various central nervous regions including the cerebral cortex and hippocampus, and are responsible for wakefulness

The role of brain noradrenergic system in the regulation of liver cytochrome P450 expression.

Anna Sadakierska-Chudy et al.

Biochemical pharmacology, 86(6), 800-807 (2013-08-09)

The aim of the present study was to examine the effect of the brain noradrenergic system on the expression of cytochrome P450 in the liver. The experiment was carried out on male Wistar rats. Intracerebroventricular injection of the noradrenergic neurotoxin

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Global Trade Item Number

SKU	GTIN
C8417-250MG	04061832090009
C8417-100MG	04061833522295

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