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Clenbuterol hydrochloride

Name: Clenbuterol hydrochloride
Brand: SIGMA

≥95% (TLC), powder, β2-adrenoceptor agonist

Synonym(s):

4-Amino-α-(t-butylaminomethyl)-3,5-dichlorobenzyl alcohol hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₈Cl₂N₂O · HCl

CAS Number:

21898-19-1

Molecular Weight:

313.65

NACRES:

NA.77

PubChem Substance ID:

24892782

UNSPSC Code:

12352200

EC Number:

244-643-7

MDL number:

MFCD00083280

Assay:

≥95%

Form:

powder

Quality level:

200

Pricing and availability is not currently available.

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Properties

Product Name

Clenbuterol hydrochloride, ≥95%

Quality Level

200

assay

≥95%

form

powder

drug control

Home Office Schedule 4.2

storage temp.

2-8°C

SMILES string

Cl.CC(C)(C)NCC(O)c1cc(Cl)c(N)c(Cl)c1

InChI

1S/C12H18Cl2N2O.ClH/c1-12(2,3)16-6-10(17)7-4-8(13)11(15)9(14)5-7;/h4-5,10,16-17H,6,15H2,1-3H3;1H

InChI key

OPXKTCUYRHXSBK-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

Description

Application

Clenbuterol hydrochloride has been used:

as an agonist for β-adrenergic receptor (β-AR) from chick skeletal muscle
to induce hypertrophic effects in masseter, digastric, and temporalis muscles of rat
as a reference β-agonist standard in tandem mass spectrometry(MS-MS)

Biochem/physiol Actions

Clenbuterol hydrochloride is a β2-adrenoceptor agonist and bronchodilator. It is effective in improving peak expiratory flow rate (PEFR) in asthma patients. Clenbuterol is also a performance-enhancing drug as it stimulates the central nervous system and improves oxygen transport. Clenbuterol elicits cardio protective functionality in patients with dilated cardiomyopathy.

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1 of 1

This Item	1134674	C2248000	SML1447
Sigma-Aldrich C5423 Clenbuterol hydrochloride	USP 1134674 Clenbuterol hydrochloride	C2248000 Clenbuterol hydrochloride	Sigma-Aldrich SML1447 Clemizole hydrochloride
form powder	form -	form -	form powder
assay ≥95%	assay -	assay -	assay ≥98% (HPLC)
drug control Home Office Schedule 4.2	drug control -	drug control -	drug control -
Quality Level 200	Quality Level -	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. 2-8°C
Gene Information human ... ADRB2(154)	Gene Information human ... ADRB2(154)	Gene Information human ... ADRB2(154)	Gene Information -

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Danger

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Repr. 1B

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A trial of clenbuterol in bronchial asthma.

Anderson G and Wilkins E

Thorax, 32(6), 717-719 (1977)

The beta-adrenoceptor agonist clenbuterol is a potent inhibitor of the LPS-induced production of TNF-alpha and IL-6 in vitro and in vivo.

C A Izeboud et al.

Inflammation research : official journal of the European Histamine Research Society ... [et al.], 48(9), 497-502 (1999-10-16)

To investigate the suppressive effects of the beta-agonist clenbuterol on the release of TNF-alpha and IL-6 in a lipopolysaccharide (LPS)-model of inflammation, both in vitro and in vivo. Human U-937 cell line (monocyte-derived macrophages), and male Wistar rats (200-250 g).

Clenbuterol residues in pig muscle after repeat administration in a growth-promoting dose.

Jelka Pleadin et al.

Meat science, 86(3), 733-737 (2010-07-30)

The aim of this study was to determine the level of clenbuterol residues in muscle tissue of pigs after repeat administration in a growth-promoting dose. An anabolic dose of clenbuterol (20 μg/kg body mass per day) was administered orally to

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Global Trade Item Number

SKU	GTIN
C5423-10MG	04061835259601
C5423-50MG	04061835259625
C5423-250MG	04061835259618

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