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Bovine Collagen Type II

Name: Bovine Collagen Type II
Brand: SIGMA

from bovine tracheal cartilage, powder

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About This Item

CAS Number:

9007-34-5

UNSPSC Code:

12352202

NACRES:

NA.61

EC Number:

232-697-4

MDL number:

MFCD00130825

Form:

powder

Biological source:

bovine cartilage (tracheal)

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Properties

Product Name

Collagen from bovine tracheal cartilage, Bornstein and Traub Type II, powder

biological source

bovine cartilage (tracheal)

Quality Segment

200

form

powder

solubility

aqueous acid: soluble

UniProt accession no.

P02459

storage temp.

2-8°C

Gene Information

cow ... COL2A1(407142)

Description

General description

Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Collagen protein is abundantly present in human. It is the prime structural constituent of dermis. It is also an important constituent of extracellular matrix (ECM).

Application

Collagen-type II has been investigated for its importance in haemostasis. Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. Collagen-type II has also been used as a model for arthritis in animals, where FR140423, a selective cyclooxygenase (COX)-2 inhibitor, has shown an anti-inflammatory effect without gastric lesions that may occur with treatment via indomethacin.

Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. However, under conditions leading to formation of reactive oxygen species, the subjects develop tolerance for auto-antibodies. This is an unusual situation of ROS having a favorable effect.[1]

Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. It has also been used as a fluorophore to acquire fluorescence emission spectra on the reflectance and fluorescence lifetime spectrometer (RFLS).

Biochem/physiol Actions

Collagen participates in the aging process. It offers a structural framework for cells and mechanical strength to tissues.

Preparation Note

Prepared by a modification of the pepsin extraction procedure of Trentham, et al., J. Exp. Med., 146, 857 (1977).

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This Item	C5608	C5483	C9791
Sigma-Aldrich C1188 Collagen from bovine tracheal cartilage	Sigma-Aldrich C5608 Collagen from rabbit skin	Sigma-Aldrich C5483 Collagen human	Sigma-Aldrich C9791 Collagen from calf skin
biological source bovine cartilage (tracheal)	biological source rabbit skin	biological source human	biological source bovine (calf) skin
form powder	form powder	form powder	form solid
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
UniProt accession no. P02459	UniProt accession no. Q28668	UniProt accession no. P08123	UniProt accession no. P02453
Gene Information cow ... COL2A1(407142)	Gene Information rabbit ... COL1A2(100008997)	Gene Information human ... COL1A2(1278)	Gene Information bovine ... COL1A1(282187)
solubility aqueous acid: soluble	solubility aqueous acid: ≤10 mg/mL, aqueous sodium acetate buffer: soluble (0.01-0.5M)	solubility aqueous acid: ≤5 mg/mL	solubility 0.1 M acetic acid: 1 mg/mL (Allow to stir at room temperature 1-3 hours until dissolved.)

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Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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