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Azaserine

Name: Azaserine
Brand: SIGMA

Hybri-Max^™, γ-irradiated, 50x, lyophilized powder, BioXtra, suitable for hybridoma

Synonym(s):

O-Diazoacetyl-L-serine

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About This Item

Empirical Formula (Hill Notation):

C₅H₇N₃O₄

CAS Number:

115-02-6

Molecular Weight:

173.13

UNSPSC Code:

12352207

NACRES:

NA.75

PubChem Substance ID:

24890511

EC Number:

204-061-6

Beilstein/REAXYS Number:

1726602

MDL number:

MFCD00036802

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Properties

grade

Hybri-Max^™

Quality Segment

200

sterility

γ-irradiated

product line

BioXtra

form

lyophilized powder

technique(s)

cell culture | hybridoma: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

fungi

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

N[C@@H](COC(=O)C=[N+]=[N-])C(O)=O

InChI

1S/C5H7N3O4/c6-3(5(10)11)2-12-4(9)1-8-7/h1,3H,2,6H2,(H,10,11)/t3-/m0/s1

InChI key

MZZGOOYMKKIOOX-VKHMYHEASA-N

Description

General description

Chemical structure: amino acid derivatives

Application

For use in hybridoma cell culture applications as a myeloma selection agent. Used to study inhibition of formylglycinamide ribonucleotide amidotransferase and PRPP amidotransferase.

Biochem/physiol Actions

Azaserine is an antibiotic, generated by Streptomyces fragilis. It is considered as a potential mutation inducing agent. It is known to promote pancreatic cancer and induces adenoma and carcinoma in vivo and in vitro. Azaserine also stimulates kidney and liver tumors in rats.

Preparation Note

Reconstitute contents of vial with 10 mL sterile cell culture medium. Stock solution is sufficient to prepare 500 mL medium. Final working concentration: 5.7 μM azaserine.

Legal Information

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

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Show Differences

1 of 1

This Item	A1287	A9666	D2141
Sigma-Aldrich A1164 Azaserine	Sigma-Aldrich A1287 5-Azacytidine	Sigma-Aldrich A9666 Azaserine-Hypoxanthine 50x	Sigma-Aldrich D2141 6-Diazo-5-oxo-L-norleucine
technique(s) cell culture \| hybridoma: suitable	technique(s) cell culture \| hybridoma: suitable	technique(s) cell culture \| hybridoma: suitable	technique(s) ligand binding assay: suitable
form lyophilized powder	form lyophilized powder	form lyophilized powder	form powder
sterility γ-irradiated	sterility γ-irradiated	sterility γ-irradiated	sterility -
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
grade Hybri-Max^™	grade Hybri-Max^™	grade Hybri-Max^™	grade -
impurities endotoxin, tested	impurities endotoxin, tested	impurities endotoxin, tested	impurities -

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pictograms

GHS06,GHS08

signalword

Danger

hcodes

H301,H351

pcodes

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Antineoplastic and Immunosuppressive Agents, Part 2, 494-494 (2013)

Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo.

Christiane Bierkamp et al.

The American journal of pathology, 165(6), 2135-2145 (2004-12-08)

The presence of gastrin and cholecystokinin-2 (CCK2) receptors in human preneoplastic and neoplastic gastrointestinal lesions suggests a role in cancer development. In addition to the growth-promoting action of gastrin, recently a role of the cholecystokinin-2/gastrin receptor (CCK2-R) modulating cellular morphology

Nitrogen-15 NMR studies of nitrogen metabolism in Picea glauca buds.

Kirsten Bagh et al.

Plant physiology and biochemistry : PPB, 42(10), 803-809 (2004-12-15)

In vivo (15)N nuclear magnetic resonance (NMR) as well as (15)N solid-state magic angle spinning (MAS) NMR spectroscopy were used to investigate nitrogen metabolism in cultured white spruce (Picea glauca) buds. Long-term as well as short-term experiments were carried out

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Global Trade Item Number

SKU	GTIN
A1164-.5MG	04061833341926

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