30058
Lipase Substrate
≥95% (HPLC)
Synonym(s):
1,2-Di-O-lauryl-rac-glycero-3-(glutaric acid 6-methylresorufin ester)
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About This Item
Empirical Formula (Hill Notation):
C45H69NO8
CAS Number:
Molecular Weight:
752.03
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Quality Level
assay
≥95% (HPLC)
form
powder
solubility
ethanol: soluble (10mg/mL)
fluorescence
λex 529 nm; λem 600 nm in 0.1 M Tris pH 8.4
storage temp.
2-8°C
SMILES string
CCCCCCCCCCCCOCC(COC(=O)CCCC(=O)Oc1ccc2N=C3C=CC(=O)C(C)=C3Oc2c1)OCCCCCCCCCCCC
InChI
1S/C45H69NO8/c1-4-6-8-10-12-14-16-18-20-22-31-50-34-38(51-32-23-21-19-17-15-13-11-9-7-5-2)35-52-43(48)25-24-26-44(49)53-37-27-28-39-42(33-37)54-45-36(3)41(47)30-29-40(45)46-39/h27-30,33,38H,4-26,31-32,34-35H2,1-3H3
InChI key
FYOMYGYHAZESGQ-UHFFFAOYSA-N
General description
Lipase substrate (1,2-Di-O-lauryl-rac-glycero-3-(glutaric,acid 6-methylresorufin) ester, DGGR) is a chromogenic substrate for lipases. It is used in colorimetric methods to measure lipase activity. This substrate produces a red-purple compound, methylresorufin, upon digestion by the lipase enzyme.
Application
Lipase Substrate is used as substrate in a high‑throughput screening assay to measure the lipase activity in response to lipstatin production
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Sébastien Cadau et al.
International journal of molecular sciences, 23(21) (2022-11-12)
Atopic dermatitis (AD), the most common inflammatory skin disorder, is a multifactorial disease characterized by a genetic predisposition, epidermal barrier disruption, a strong T helper (Th) type 2 immune reaction to environmental antigens and an altered cutaneous microbiome. Microbial dysbiosis
Michal Híreš et al.
Current microbiology, 75(5), 580-587 (2017-12-20)
Pancreatic lipase inhibitors, such as tetrahydrolipstatin (orlistat), are used in anti-obesity treatments. Orlistat is the only anti-obesity drug approved by the European Medicines Agency (EMA). The drug is synthesized by saturation of lipstatin, a β-lactone compound, isolated from Streptomyces toxytricini
Yan Q Chen et al.
Journal of lipid research, 61(8), 1203-1220 (2020-06-04)
Angiopoietin-like protein (ANGPTL)8 has been implicated in metabolic syndrome and reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to regulate LPL. In human serum
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 30058-50MG-F | 04061826659335 |
| 30058-10MG-F | 04061826659328 |