No information is available on dissolving directly in DMSO or PBS. Resuspension in 1% NH4OH at a concentration of 1 mg/mL is recommended. Sonicate for 30 seconds to 1 minute after the solution is achieved. To prepare the final solution, add 5x or 10x buffer stock (PBS, TBS) and water to achieve a 1x buffer concentration.
AG968
β Amyloid 1-42, aβ, ultra pure, HFIP, recombinant human
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About This Item
UNSPSC Code:
12352202
NACRES:
NA.41
eCl@ss:
32160405
Form:
(Clear dry film)
Assay:
>97.0%
Biological source:
human
Pricing and availability is not currently available.
biological source
human
Quality Level
assay
>97.0%
form
(Clear dry film)
manufacturer/tradename
Chemicon®
NCBI accession no.
UniProt accession no.
Gene Information
human ... APP(351)
General description
β Amyloid 1-42 is a derivative of integral membrane-bound amyloid precursor protein. It is the most important alloform of the Alzheimer′s peptide.
Application
β Amyloid 1-42, aβ, ultra-pure, HFIP, recombinant human has been used:
- to study its effect on the activity of mitochondrial BKCa (mitoBKCa) channels in human astrocytoma cells through patch-clamp technique
- to study its effect on alteration in protein levels of dystrophic neurites (DNs) forming proteins in mouse neuroblastoma cells
- to induce Alzheimer′s disease in a rat model for experimental studies
Biochem/physiol Actions
β Amyloid 1-42 causes neurotoxicity and is implicated in the pathogenesis of Alzheimer′s disease (AD). β Amyloid (βA) acts as a ligand for several receptors and other molecules involved in complex trafficking pathways in tissues and blood-brain barriers. βA along with amylin elevates cyclic adenosine monophosphate (cAMP) and Ca2+ in turn activates multiple signaling pathway mediators like mitogen-activated protein kinase (MAPK), protein kinase A/B, and cFOS. It acts as the main source of AD-associated neuroinflammation.
Preparation Note
Clear dry film. Resuspend in 1% NH4OH at a concentration of 1 mg/mL. Sonicate for 30 seconds to 1 minute after it has gone into solution. To bring into your solution: After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring to 1x buffer.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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This Item | |||
|---|---|---|---|
| assay >97.0% | assay >97.0% | assay >97.0% | assay >97% |
| biological source human | biological source human | biological source human | biological source human |
| form (Clear dry film) | form powder | form powder | form powder |
| Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) | Gene Information human ... APP(351) |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| NCBI accession no. | NCBI accession no. | NCBI accession no. | NCBI accession no. |
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Annika Olsson et al.
Clinical chemistry, 51(2), 336-345 (2004-11-26)
To simultaneously study several biomarkers for Alzheimer disease (AD), we used the xMAP technology to develop and evaluate a multiparametric bead-based assay for quantification of beta-amyloid((1-42)) [Abeta((1-42))], total tau (T-TAU), and hyperphosphorylated tau [P-TAU((181P))] in cerebrospinal fluid (CSF). We compared
Stephanie J Soscia et al.
PloS one, 5(3), e9505-e9505 (2010-03-09)
The amyloid beta-protein (Abeta) is believed to be the key mediator of Alzheimer's disease (AD) pathology. Abeta is most often characterized as an incidental catabolic byproduct that lacks a normal physiological role. However, Abeta has been shown to be a
Ye Ji Lee et al.
Frontiers in molecular neuroscience, 16, 1150399-1150399 (2023-05-05)
Growth-associated protein 43 (GAP-43) is known as a neuronal plasticity protein because it is widely expressed at high levels in neuronal growth cones during axonal regeneration. GAP-43 expressed in mature adult neurons is functionally important for the neuronal communication of
Global Trade Item Number
| SKU | GTIN |
|---|---|
| AG968-1MG | 04053252513930 |
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Can I dissolve and use the product directly in DMSO or PBS upon receiving it, or is it necessary to first resuspend it in 1% NH4OH, then add PBS and water to adjust the concentration as described in the answer to the above question?
1 answer-
Helpful?
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What's the molecular weight and solubility of β Amyloid 1-42 (AG968)?
1 answer-
This material has a molecular weight of 4514.2 Daltons and may be resuspended at 1 mg/mL in 1% NH4OH with sonication for 30 seconds to 1 minute. After resuspension, add 5x or 10x buffer stock (PBS, TBS) and water to bring the concentration to 1x.
Helpful?
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