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Pirenzepine dihydrochloride

Name: Pirenzepine dihydrochloride
Brand: SIGMA

≥98% (TLC), muscarinic acetylcholine receptor antagonist, powder

Synonym(s):

5,11-Dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₁N₅O₂ · 2HCl

CAS Number:

29868-97-1

Molecular Weight:

424.32

NACRES:

NA.77

PubChem Substance ID:

24277863

UNSPSC Code:

12352200

EC Number:

249-907-5

MDL number:

MFCD00055214

Assay:

≥98% (TLC)

Form:

powder

Pricing and availability is not currently available.

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Properties

Product Name

Pirenzepine dihydrochloride, ≥98% (TLC), powder

Quality Segment

200

assay

≥98% (TLC)

form

powder

color

white to light yellow

solubility

H₂O: 50 mg/mL

SMILES string

Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24

InChI

1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H

InChI key

FFNMBRCFFADNAO-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

Description

General description

Pirenzepine dihydrochloride is an anticholinergic agent. It is also considered as an antiulcer drug. It is used to treat myopia, gastric and duodenal ulcers. Pirenzepine dihydrochloride induces the dimerization of muscarinic M1 receptors.

Application

Pirenzepine dihydrochloride has been used

in transactivation of fibroblast growth factor receptor (FGFR).
as a supplement in cell culture.
for the stimulation of human fibroblasts

Biochem/physiol Actions

Selective M₁ muscarinic acetylcholine receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Disclaimer

Hygroscopic; store desiccated at room temperature.

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This Item	T122	D4526	C7291
Sigma-Aldrich P7412 Pirenzepine dihydrochloride	Sigma-Aldrich T122 Telenzepine dihydrochloride hydrate	Sigma-Aldrich D4526 Doxepin hydrochloride	Sigma-Aldrich C7291 Clomipramine hydrochloride
assay ≥98% (TLC)	assay ≥98% (HPLC)	assay ≥98% (GC)	assay ≥98% (HPLC)
form powder	form solid	form powder	form powder
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
solubility H₂O: 50 mg/mL	solubility H₂O: >10 mg/mL	solubility 1 M HCl: 50 mg/mL, H₂O: soluble	solubility H₂O: 25 mg/mL, 0.1 M HCl: soluble
color white to light yellow	color white	color white to off-white	color white to off-white
Gene Information human ... CHRM1(1128)	Gene Information human ... CHRM1(1128)	Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), HRH1(3269), HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)	Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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