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PP1

Name: PP1
Brand: SIGMA

≥98% (HPLC), PTK inhibitor, powder

Synonym(s):

4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₉N₅

CAS Number:

172889-26-8

Molecular Weight:

281.36

UNSPSC Code:

12352200

PubChem Substance ID:

329819992

NACRES:

NA.77

MDL number:

MFCD01076570

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Pricing and availability is not currently available.

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Properties

Product Name

PP1, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C

InChI

1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

InChI key

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Description

Application

PP1 has been used as:

an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn[1]
a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth[2]
a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)[3]

Biochem/physiol Actions

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

PP1 is a pyrazolopyrimidine compound[4] that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding.[5] It also inhibits protein tyrosine kinase (PTK6)[4] and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.[4]

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Show Differences

1 of 1

This Item	P0042	P0036	PZ0357
Sigma-Aldrich P0040 PP1	Sigma-Aldrich P0042 PP2	Sigma-Aldrich P0036 PP121	Sigma-Aldrich PZ0357 PF-06412562
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. room temp
solubility DMSO: >20 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: 30 mg/mL, clear
color white to off-white	color white to off-white	color off-white	color white to beige

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

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CEACAM1 long isoform has opposite effects on the growth of human mastocytosis and medullary thyroid carcinoma cells.

Chiyuki Ueshima et al.

Cancer medicine, 6(4), 845-856 (2017-03-24)

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed in a number of tumor cell types. The immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing isoforms of this molecule which possess a long cytoplasmic tail (CEACAM1-L) generally play inhibitory roles in cell function

Molecular characterization of neuropeptide Y (NPY) receptors (Y1, Y4 and Y6) and investigation of the tissue expression of their ligands (NPY, PYY and PP) in chickens.

Shunyu Gao et al.

General and comparative endocrinology, 240, 46-60 (2016-10-23)

Neuropeptide Y (NPY) receptors and its ligands, NPY, peptide YY (PYY) and pancreatic polypeptide (PP), are suggested to regulate many physiological processes including food intake in birds. However, our knowledge regarding this avian NPY system remains rather limited. Here, we

M2-like macrophages induce colon cancer cell invasion via matrix metalloproteinases.

Katyayni Vinnakota et al.

Journal of cellular physiology, 232(12), 3468-3480 (2017-01-18)

The inflammatory milieu plays an important role in colon cancer development and progression. Previously, we have shown that tumor-associated macrophages (TAMs), an important component of the tumor microenvironment, are enriched in tumors compared with normal tissue and confer a poorer

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Global Trade Item Number

SKU	GTIN
P0040-5MG	04061834262039
P0040-25MG	04061833220016

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