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APHA Compound 8

Name: APHA Compound 8
Brand: SIGMA

solid, ≥98% (HPLC)

Synonym(s):

3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆N₂O₃

CAS Number:

676599-90-9

Molecular Weight:

284.31

MDL number:

MFCD29074969

UNSPSC Code:

12352202

PubChem Substance ID:

329770785

NACRES:

NA.77

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Properties

Product Name

APHA Compound 8, ≥98% (HPLC), solid

Quality Segment

100

assay

≥98% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cn1cc(cc1\C=C\C(=O)NO)C(=O)Cc2ccccc2

InChI

1S/C16H16N2O3/c1-18-11-13(10-14(18)7-8-16(20)17-21)15(19)9-12-5-3-2-4-6-12/h2-8,10-11,21H,9H2,1H3,(H,17,20)/b8-7+

InChI key

UFQOXIMRSMFQRI-BQYQJAHWSA-N

Description

Biochem/physiol Actions

HDAC (histone deacetylase) inhibitor.

One of a class of aroyl pyrrole hydroxy amide (APHA) compounds showing histone deacetylase (HDAC) inhibition, Compound 8 is the most potent and HDAC class I-selective.

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This Item	SML3060	A9227	S5192
Sigma-Aldrich A2478 APHA Compound 8	Sigma-Aldrich SML3060 Panobinostat	Sigma-Aldrich A9227 ABT-491 hydrochloride	Sigma-Aldrich S5192 SB 222200
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
form solid	form powder	form solid	form solid
solubility DMSO: >10 mg/mL, H₂O: insoluble	solubility DMSO: 2 mg/mL, clear	solubility H₂O: freely soluble 22 mg/mL	solubility DMSO: soluble ~28 mg/mL, H₂O: insoluble
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C