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O4375

Oxytocin

Name: Oxytocin
Brand: SIGMA

lyophilized powder, ~15 IU/mg solid (Prepared from synthetic oxytocin)

Synonyme(s) :

α-Hypophamine, Oxytocic hormone

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Conditionnement	Référence	Disponibilité	Prix

A propos de cet article

Formule empirique (notation de Hill) :

C₄₃H₆₆N₁₂O₁₂S₂

Numéro CAS:

50-56-6

Poids moléculaire :

1007.19

UNSPSC Code:

51111800

NACRES:

NA.32

PubChem Substance ID:

24897994

MDL number:

MFCD00076731

Beilstein/REAXYS Number:

3586108

Biological source:

synthetic

Form:

lyophilized powder

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Propriétés

biological source

synthetic

Quality Level

200

sterility

non-sterile

form

lyophilized powder

specific activity

~15 IU/mg solid (Prepared from synthetic oxytocin)

solubility

water: 10 mg/mL, clear, colorless

UniProt accession no.

P01178, P30559, P70536

shipped in

ambient

storage temp.

2-8°C

SMILES string

[H]N[C@H]1CSSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc2ccc(O)cc2)NC1=O)[C@@H](C)CC)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O

InChI

1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)/t22-,25-,26-,27-,28-,29-,30-,31-,35-/m0/s1

InChI key

XNOPRXBHLZRZKH-DSZYJQQASA-N

Gene Information

human ... OXT(5020), OXTR(5021)
rat ... Oxtr(25342)

Description

General description

Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns where first exon codes for hormone OXT while other exon codes for neurophysin I.

Application

Oxytocin has been used in immunocytochemistry analysis and it has also been used to study the mechanism responsible for the reduced ability of mice deficient in plasminogen (Plg) to support a litter during lactation.

Biochem/physiol Actions

Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).

Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.

Physical form

Lyophilized powder containing 3% oxytocin with mannitol and buffer salts.

Comparer avec des articles similaires

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1 of 1

Cet article	O3251	1491300	O0700000
Sigma-Aldrich O4375 Oxytocin	Sigma-Aldrich O3251 Oxytocin	USP 1491300 Oxytocin	O0700000 Oxytocin
biological source synthetic	biological source synthetic (organic)	biological source -	biological source -
Quality Level 200	Quality Level 200	Quality Level -	Quality Level -
form lyophilized powder	form lyophilized powder	form powder	form -
solubility water: 10 mg/mL, clear, colorless	solubility -	solubility -	solubility -
shipped in ambient	shipped in ambient	shipped in -	shipped in -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. -	storage temp. -

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11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

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Intranasal oxytocin and a polymorphism in the oxytocin receptor gene are associated with human-directed social behavior in golden retriever dogs.

Mia E Persson et al.

Hormones and behavior, 95, 85-93 (2017-08-03)

The oxytocin system may play an important role in dog domestication from the wolf. Dogs have evolved unique human analogue social skills enabling them to communicate and cooperate efficiently with people. Genomic differences in the region surrounding the oxytocin receptor

Progesterone receptor isoform B regulates the Oxtr-Plcl2-Trpc3 pathway to suppress uterine contractility.

Mary C Peavey et al.

Proceedings of the National Academy of Sciences of the United States of America, 118(11) (2021-03-13)

Uterine contractile dysfunction leads to pregnancy complications such as preterm birth and labor dystocia. In humans, it is hypothesized that progesterone receptor isoform PGR-B promotes a relaxed state of the myometrium, and PGR-A facilitates uterine contraction. This hypothesis was tested

Motherhood and oxytocin receptor genetic variation are associated with selective changes in electrocortical responses to infant facial expressions.

Mikko J Peltola et al.

Emotion (Washington, D.C.), 14(3), 469-477 (2014-04-23)

Recent studies suggest that parental caregiving is associated with adaptive changes in neurocognitive responses to emotional cues and oxytocin function, possibly reflecting the increased need of parents to monitor infants' emotional states. In the current study, we investigated whether the

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Numéro d'article de commerce international

Référence	GTIN
O4375-250IU	04061834233824
O4375-1000IU	04061834233800

Questions

Anonymous

2 years ago

I was wondering how many times Oxytocin lyophilized powder can be stored once it is diluted.

1 answer
1. Technical Support
  
  2 years ago
  
  The stability of Oxytocin concentrates stored at various temperatures for 48 months was evaluated regularly for biological activity on rat uteri. It was found that concentrates kept in a refrigerator showed no loss of oxytocin activity, while samples kept at 21°C showed a slight loss of activity (about 1.5% per year), and those at 30°C showed a marked loss of activity (about 10% per year). Similar results were obtained with dilute injections of oxytocin. The study concluded that oxytocin in solution has a shelf life of 3 years at 21°C but should not be exposed to higher temperatures (Nachtmann et al. 1981).
  In a simulation study conducted by WHO in collaboration with IDA Foundation, two batches of three brands of oxytocin ampoules were stored at different temperatures and samples were assayed for oxytocin content over a period of 2 years (Hogerzeil et al. 1993). Based on the results (Figure 2), WHO and IDA suggested the following guidelines for the shelf life of oxytocin injections at higher temperatures:
  - At 2°C- 8°C, shelf life of 3 years.
  - Below 21°C, shelf life of 2 years.
  - At 25°C, the shelf life is reduced to 1 year.
  - At 30°C, the shelf life is reduced to 6 months.
  - At 40°C transport maximum 1 week.
  
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