L9664

Loratadine

≥98% (HPLC), Histamine H1 receptor antagonist, powder

• Synonym(s): 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester, Loratidine
• Empirical Formula (Hill Notation): C₂₂H₂₃N₂O₂Cl
• CAS Number: 79794-75-5
• Molecular Weight: 382.88
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278525
• NACRES: NA.77
• MDL number: MFCD00672869
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Loratadine, ≥98% (HPLC), powder
• Quality Segment: 200
• assay: ≥98% (HPLC)
• form: powder
• color: white
• solubility: DMSO: soluble 50 mg/mL, H₂O: insoluble
• originator: Schering Plough
• storage temp.: 2-8°C
• SMILES string: CCOC(=O)N1CC\C(CC1)=C2/c3ccc(Cl)cc3CCc4cccnc24
• InChI: 1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3
• InChI key: JCCNYMKQOSZNPW-UHFFFAOYSA-N
• Gene Information: human ... CYP3A4(1576), HRH1(3269), KCNH1(3756), KCNH2(3757), PTAFR(5724) ; rat ... Hrh1(24448)

Description

Biochem/physiol Actions

Loratadine is a non-sedating histamine H1-receptor antagonist. Shown to inhibit the two-pore domain potassium channel K2P18.1 (also called TRESK or KCNK18).

Non-sedating histamine H₁-receptor antagonist.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)