This product is prepared in water at approximately 1.0 g/mL. The concentration may range from 5.8 - 6.1M or 0.947 - 1.05 g/mL. The lot-specific molarity of this solution is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot-specific Certficate:
https://www.sigmaaldrich.com/product/sigma/t0699#product-documentation
T0699
Trichloroacetic acid solution
6.1 N
Synonym(s):
TCA
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About This Item
Linear Formula:
Cl3CCOOH
CAS Number:
Molecular Weight:
163.39
UNSPSC Code:
12352106
NACRES:
NA.26
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
970119
Concentration:
6.1 N, ~100 % (w/v)
Form:
liquid
Pricing and availability is not currently available.
form
liquid
Quality Level
concentration
6.1 N, ~100 % (w/v)
SMILES string
OC(=O)C(Cl)(Cl)Cl
InChI
1S/C2HCl3O2/c3-2(4,5)1(6)7/h(H,6,7)
InChI key
YNJBWRMUSHSURL-UHFFFAOYSA-N
General description
Trichloroacetic acid (TCA) is a strong acid. At the pH of drinking water, TCA exists almost in salt form.
Application
Trichloroacetic acid solution has been used:
- in indoleamine 2,3-dioxygenase (IDO) enzyme assay to hydrolyze N-formylkynurenine and produce kynurenine
- in the proliferation of human pulmonary artery smooth muscle cells (HPASMCs)
- to treat ground tissue and precipitate proteins during protein extraction and quantification
Biochem/physiol Actions
Trichloroacetic acid solution is traditionally used to precipitate protein. It can be used to determine protein concentration by quantitative precipitation. Trichloroacetic acid can also be used as a decalcifier and fixative in microscopy.
Trichloroacetic acid (TCA) with no known systemic toxicity, is used as a time-honored agent for superficial peeling. It is a peroxisome proliferator.
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| concentration 6.1 N, ~100 % (w/v) | concentration - | concentration - | concentration - |
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| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
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signalword
Danger
hcodes
target_organs
Respiratory system
Storage Class
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1 - STOT SE 3
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Guillaume Laflamme et al.
Cell reports, 26(11), 2875-2889 (2019-03-14)
The segregation of chromosomes is a critical step during cell division. This process is driven by the elongation of spindle microtubules and is tightly regulated by checkpoint mechanisms. It is unknown whether microtubules affect checkpoint responses as passive contributors or
Alan Mortensen et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 55-62 (2012-10-17)
The ratio of the nitric oxide synthase (NOS) cofactor tetrahydrobiopterin (BH(4)) to its oxidized form dihydrobiopterin (BH(2)) has been suggested as an index of endothelial dysfunction. Consequently, much effort has been put into preserving the in vivo equilibrium between these
Valentina Folgiero et al.
Oncotarget, 5(8), 2052-2064 (2014-06-07)
Microenvironmental factors contribute to the immune dysfunction characterizing acute myeloid leukemia (AML). Indoleamine 2,3-dioxygenase 1 (IDO1) is an interferon (IFN)-γ-inducible enzyme that degrades tryptophan into kynurenine, which, in turn, inhibits effector T cells and promotes regulatory T-cell (Treg) differentiation. It
Global Trade Item Number
| SKU | GTIN |
|---|---|
| T0699-100ML | 04061837335778 |
| T0699-30ML | 04061837731518 |
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Is solution prepared in water at 1g/ml concentration?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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