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SML0853

SB 699551 dihydrochloride

≥98% (HPLC)

Synonym(s):

N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C34H45N3O · 2HCl
CAS Number:
Molecular Weight:
584.66
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

H2O: 1 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

Cl.Cl.N(CCN(Cc2ccc(cc2)c3ccc(cc3)CNCCc4ccccc4)C(=O)CCC1CCCC1)(C)C

InChI

1S/C34H45N3O.2ClH/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29;;/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3;2*1H

InChI key

QJMKBIHLMPTYTI-UHFFFAOYSA-N

Application

SB 699551 dihydrochloride has been used to identify the antagonism of 5-HT2AR in cell culture-derived hepatitis C virus (HCVcc).

Biochem/physiol Actions

SB-699551 is 5-HT5A receptor antagonist.
SB-699551 is a 5-HT5A receptor antagonist, (pKi = 8.3) with 100-fold selectivity over other 5-HT receptor populations. SB-699551 completely blocks 5-HT-induced [35S]GTPγS membrane binding in cells expressing recombinant guinea pig 5-HT-5A.
SB 699551 dihydrochloride is also known as (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4′-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride). It is considered as a useful tool to explain the physiological roles of the 5-ht5A receptor.

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This Item
SML0638D2571SML0667
form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: 1 mg/mL, clear (warmed)

solubility

DMSO: 10 mg/mL, clear

solubility

H2O: 16 mg/mL

solubility

H2O: 15 mg/mL, clear

color

white to beige

color

white to light brown

color

white

color

white to beige


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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