SML0070

Salsalate

≥98% (HPLC), COX inhibitor, powder

• Synonym(s): 2-(2-Hydroxybenzoyl)oxybenzoic acid, 2-Hydroxybenzoic acid 2-carboxyphenyl ester, disalicylic acid, salicyloxysalicylic acid, salicylsalicylic acid
• Empirical Formula (Hill Notation): C₁₄H₁₀O₅
• CAS Number: 552-94-3
• Molecular Weight: 258.23
• NACRES: NA.77
• PubChem Substance ID: 329825134
• UNSPSC Code: 12352200
• EC Number: 209-027-4
• MDL number: MFCD00020252
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: Salsalate, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• storage temp.: room temp
• SMILES string: OC(=O)c1ccccc1OC(=O)c2ccccc2O
• InChI: 1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
• InChI key: WVYADZUPLLSGPU-UHFFFAOYSA-N

Description

Application

Salsalate was used to study the effect on palmitate-induced insulin resistance[1] and hepatic steatosis in obese rats.[2]

Biochem/physiol Actions

NSAID; Nonacetylated aspirin analog

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Warning
• hcodes: H302,H315,H319,H361d,H412
• pcodes: P202 - P273 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable