O0877

Oxolinic acid

quinolone antibiotic

• Synonym(s): 5,8-Dihydro-5-ethyl-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid
• Empirical Formula (Hill Notation): C₁₃H₁₁NO₅
• CAS Number: 14698-29-4
• Molecular Weight: 261.23
• UNSPSC Code: 51282935
• NACRES: NA.85
• PubChem Substance ID: 24278604
• EC Number: 238-750-8
• Beilstein/REAXYS Number: 620635
• MDL number: MFCD00056775

Properties

• Quality Segment: 200
• antibiotic activity spectrum: Gram-negative bacteria
• mode of action: DNA synthesis | interferes, enzyme | inhibits
• storage temp.: 2-8°C
• SMILES string: CCN1C=C(C(O)=O)C(=O)c2cc3OCOc3cc12
• InChI: 1S/C13H11NO5/c1-2-14-5-8(13(16)17)12(15)7-3-10-11(4-9(7)14)19-6-18-10/h3-5H,2,6H2,1H3,(H,16,17)
• InChI key: KYGZCKSPAKDVKC-UHFFFAOYSA-N

Description

General description

Chemical structure: quinolone

Application

Oxolinic acid is used to study new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6′)Ib-cr, in Escherichia coli and Salmonella enterica. Oxolinic acid is added to culture medium for the isolation of Gardnerella vaginalis.

Biochem/physiol Actions

Oxolinic acid is a quinolone antibiotic. It is a DNA-gyrase (topoisomerase II) inhibitor used for studies on DNA winding and coiling and acts as a dopamine reuptake inhibitor for studies on dopaminergic neurotransmission processes.

Other Notes

5g,25g

Keep container tightly closed in a dry and well-ventilated place.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves