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2′,5′-Dideoxyadenosine

Name: 2&#8242;,5&#8242;-Dideoxyadenosine
Brand: SIGMA

≥95% (HPLC), Adenylyl cyclase inhibitor, solid

Synonym(s):

2ʹ,5ʹ-dd-Ado, NSC 95943

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₃N₅O₂

CAS Number:

6698-26-6

Molecular Weight:

235.24

UNSPSC Code:

41106305

PubChem Substance ID:

24894132

NACRES:

NA.77

MDL number:

MFCD00210904

Assay:

≥95% (HPLC)

Form:

solid

Quality level:

100

Pricing and availability is not currently available.

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Properties

Product Name

2′,5′-Dideoxyadenosine, ≥95% (HPLC), solid

Quality Level

100

assay

≥95% (HPLC)

form

solid

color

white

solubility

DMSO: soluble

storage temp.

−20°C

SMILES string

C[C@H]1O[C@H](C[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C10H13N5O2/c1-5-6(16)2-7(17-5)15-4-14-8-9(11)12-3-13-10(8)15/h3-7,16H,2H2,1H3,(H2,11,12,13)/t5-,6+,7-/m1/s1

InChI key

FFHPXOJTVQDVMO-DSYKOEDSSA-N

Gene Information

rat ... Adcy2(81636)

Description

Application

2′,5′-Dideoxyadenosine has been used to elucidate the mechanism of diligustilide (DLG). It has also been used to inhibit adenylate cyclase (AC).

Biochem/physiol Actions

Cell-permeable adenylyl cyclase inhibitor. IC₅₀ = 2.7 μM in detergent-dispersed rat brain preparations.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Store at −20 °C after reconstitution.

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1 of 1

This Item	288104	D8190	D1068
Sigma-Aldrich D7408 2′,5′-Dideoxyadenosine	Sigma-Aldrich 288104 2′,5′-Dideoxyadenosine	Sigma-Aldrich D8190 3′,4′-Dichlorobenzamil hydrochloride	Sigma-Aldrich D1068 DCB
assay ≥95% (HPLC)	assay ≥98% (HPLC)	assay >98% (HPLC)	assay ≥98% (HPLC)
form solid	form solid	form solid	form solid
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: soluble	solubility DMSO: 10 mg/mL	solubility DMSO: soluble 30 mg/mL, H₂O: insoluble	solubility DMSO: ~6.8 mg/mL, H₂O: insoluble
color white	color white	color yellow	color yellow

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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miR‑351‑5p aggravates lipopolysaccharide‑induced acute lung injury via inhibiting AMPK.

Fen Hu et al.

Molecular medicine reports, 24(4) (2021-07-31)

Inflammation and oxidative stress have indispensable roles in the development of acute lung injury (ALI). MicroRNA (miRNA/miR)‑351‑5p was initially identified as a myogenesis‑associated miRNA; however, its role in lipopolysaccharide (LPS)‑induced ALI remains unclear. The aim of the present study was

Impaired complement-mediated phagocytosis by HIV type-1-infected human monocyte-derived macrophages involves a cAMP-dependent mechanism.

Rula Azzam et al.

AIDS research and human retroviruses, 22(7), 619-629 (2006-07-13)

HIV-1 infection of cells of macrophage lineage impairs a number of effector functions performed by these cells, including phagocytosis of opsonized pathogens. In this study we investigate the effects of HIV-1 on the mechanism of complement (C')-mediated phagocytosis by human

Prostaglandin E(2) protects human lung fibroblasts from cigarette smoke extract-induced apoptosis via EP(2) receptor activation.

Hisatoshi Sugiura et al.

Journal of cellular physiology, 210(1), 99-110 (2006-09-26)

Prostaglandin E(2) (PGE(2)) has been shown to have a strong cytoprotective effect, inhibiting apoptosis. In the present study, we evaluated whether PGE(2) has a protective effect on cigarette smoke extract (CSE)-induced apoptosis in human lung fibroblasts. Apoptosis was assessed by

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Global Trade Item Number

SKU	GTIN
D7408-25MG	04061832897868
D7408-5MG	04061833588512

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