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7,8-Dihydroxyflavone hydrate

Name: 7,8-Dihydroxyflavone hydrate
Brand: SIGMA

≥98% (HPLC), Selective TrkB receptor agonist, solid

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About This Item

Empirical Formula (Hill Notation):

C₁₅H₁₀O₄ · xH₂O

CAS Number:

38183-03-8

Molecular Weight:

254.24 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329798806

UNSPSC Code:

12352200

EC Number:

253-812-4

MDL number:

MFCD00006836

Assay:

≥98% (HPLC)

Form:

solid

Storage condition:

desiccated

Pricing and availability is not currently available.

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Properties

Product Name

7,8-Dihydroxyflavone hydrate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

solubility

DMSO: 24 mg/mL

storage temp.

room temp

SMILES string

Oc1ccc2C(=O)C=C(Oc2c1O)c3ccccc3

InChI

1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H

InChI key

COCYGNDCWFKTMF-UHFFFAOYSA-N

Description

Application

7,8-Dihydroxyflavone hydrate has been used as tropomyosin-receptor-kinase B (TrkB) agonist in mice and to inhibit TrkB for monitoring evoked excitatory postsynaptic currents (eEPSCs).

Biochem/physiol Actions

7,8-Dihydroxyflavone is a selective TrkB receptor agonist

7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)—such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease—without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.

7,8-Dihydroxyflavone (7,8-DHF) may be used to help identify and differentiate the physiological effects and cell signaling pathways mediated by TrkB activation, such as those involving, memory, vasorelaxation and hypertension. 7,8-DHF elicits protection in scopolamine induced Alzheimer-like pathologic dysfunction.

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Show Differences

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This Item	M6316	L1045	O1385
Sigma-Aldrich D5446 7,8-Dihydroxyflavone hydrate	Sigma-Aldrich M6316 MRS 1754 hydrate	Sigma-Aldrich L1045 LY-354740 hydrate	Sigma-Aldrich O1385 Ozagrel hydrochloride hydrate
form solid	form solid	form solid	form solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp
solubility DMSO: 24 mg/mL	solubility DMSO: soluble >10 mg/mL	solubility deionized water: 8 mg/mL	solubility H₂O: soluble
storage condition desiccated	storage condition -	storage condition -	storage condition desiccated

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000497077

0000492058

0000472590

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Global Trade Item Number

SKU	GTIN
D5446-10MG	04061833586266
D5446-50MG	04061833586273

Questions

Anonymous

2 years ago

What are the recommended storage conditions for D5446 after reconstitution?

1 answer
1. Technical Support
  
  2 years ago
  
  Although there is no datasheet available for product D5446, there is information available for a product sharing the same CAS number from a different division. Below is the information found for product 506300 (7,8 Dihydroxyflavone):
  - Solubility: DMSO (100 mg/ml)
  - Storage: Protect from light, +2°C to +8°C
  - Do Not Freeze: Ok to freeze
  - Special Instructions: Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
  This information will also apply for product D5446. There are additional notes stating the product is packaged under inert gas. Therefore, if storing, it would be best to leave no air space in the storage container if possible. If that is not possible, it would be best to store under either dry nitrogen or argon.
  
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