The product should be stored at room temperature upon receipt. It is soluble in water at a concentration greater than 10 mg/ml. However, stock solutions should be stored at -20°C.
C5976
CL 316,243 hydrate
≥98% (HPLC), powder, β3 adrenoceptor agonist
Synonym(s):
Disodium 5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate hydrate
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About This Item
Empirical Formula (Hill Notation):
C20H18ClNNa2O7 · xH2O
CAS Number:
Molecular Weight:
465.79 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Pricing and availability is not currently available.
Product Name
CL 316,243 hydrate, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 10 mg/mL, clear
originator
Wyeth
storage temp.
room temp
SMILES string
O.[Na+].[Na+].C[C@H](Cc1ccc2OC(Oc2c1)(C([O-])=O)C([O-])=O)NC[C@H](O)c3cccc(Cl)c3
InChI
1S/C20H20ClNO7.2Na.H2O/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;;1H2/q;2*+1;/p-2/t11-,15+;;;/m1.../s1
InChI key
BFEWLXURNRQQLY-BELDDISZSA-L
Gene Information
human ... ADRB3(155)
Application
CL 316,243 hydrate has been used:
- as a β-agonists to inject mice and study its effect on the expression of mammalian major facilitator superfamily domain-containing protein (Mfsd2a)
- as an adrenergic agonist to stimulate adrenergic response in order to study the metabolic activity of brown, beige and white adipose tissues in mice
- as a β3-adrenergic agonist to inject mice for in vivo lipolytic challenge
Biochem/physiol Actions
CL 316,243 is a β3 adrenoceptor agonist; anti-obesity agent.
β Adrenoceptor is expressed in a number of tissues such as heart, adipose tissue, colon and other tissues. It is associated with many different biological functions. β Adrenoceptor fills in as an objective for treating type 2 diabetes, heart failure, cachexia, obesity, metabolic disorder, issues related with bladder, colon and malignant tumor growth. Depression and anxiety can also be treated via β adrenoceptor. CL 316,243 is known to have antidiabetic action via β adrenoceptor. It is a potent stimulator of lipolysis. It also activates β3- adrenoceptors on neurons in hypothalamic areas that are important in the central regulation of appetite.
Features and Benefits
This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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This Item | |||
|---|---|---|---|
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥98% (HPLC) |
| form powder | form solid | form solid | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. - | storage temp. room temp | storage temp. room temp |
| solubility H2O: 10 mg/mL, clear | solubility DMSO: 18 mg/mL, clear (warmed) | solubility H2O: ≥5 mg/mL | solubility DMSO: >10 mg/mL |
| originator Wyeth | originator - | originator - | originator Boehringer Ingelheim |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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What are the best storage conditions for item C5976 upon receipt? Also, what solvent is ideal for preparing stock solutions, and how should stock solutions be stored?
1 answer-
Helpful?
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What temperature to store once mixed with H2O?
1 answer-
Solutions should be prepared fresh and used the same day. Other sources suggest the solution may be stable when stored in tightly sealed aliquots at -20°C for up to 1 month. This information has not been validated.
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