C4911

Chlorothiazide

synthetic (organic), ≥98% (HPLC), carbonic anhydrase inhibitor, powder

• Synonym(s): 6-Chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Empirical Formula (Hill Notation): C₇H₆ClN₃O₄S₂
• CAS Number: 58-94-6
• Molecular Weight: 295.72
• NACRES: NA.77
• PubChem Substance ID: 24278150
• UNSPSC Code: 12352202
• EC Number: 200-404-9
• MDL number: MFCD00058576

Properties

• Product Name: Chlorothiazide, thiazide diuretic
• biological source: synthetic (organic)
• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• mp: >300 °C
• solubility: DMF: 50 mg/mL, clear, colorless to very faintly yellow
• storage temp.: 2-8°C
• SMILES string: O=S(C1=C2C=C(Cl)C(S(N)(=O)=O)=C1)(NC=N2)=O
• InChI: 1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
• InChI key: JBMKAUGHUNFTOL-UHFFFAOYSA-N
• Gene Information: human ... CA1(759), CA4(762), SLC12A3(6559)

Description

General description

Chlorothiazide (CTLD) is a thiazide-like diuretics and has antihypertensive effects.[1]

Application

One of the first in the thiazide class of diuretics.

Chlorothiazide has been used as a reference standard in parallel artificial membrane permeability assay (PAMPA). It has also been used to test its effect on blocking pendrin activity.[2]

Biochem/physiol Actions

Chlorothiazide (CTLD) shows structural resemblance with hydrochlorothiazide by having a sulfonamide group, but exhibits a long action duration.[3] CTLD is an inhibitor of carbonic anhydrase and is more potent than hydrochlorothiazide.[3]

Safety Information

• pictograms: GHS08
• signalword: Danger
• hcodes: H317,H334
• pcodes: P261 - P272 - P280 - P284 - P302 + P352 - P333 + P313
• Hazard Classifications: Resp. Sens. 1 - Skin Sens. 1
• Storage Class: 11 - Combustible Solids
• wgk: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves