C4382 (98%) and C2409 (99%) are the same chemical with slightly different purity specifications. Product No. C2409 is no longer available.
C4382
Carbamoylcholine chloride
≥98% (titration), Non-selective cholinergic agonist, crystalline
Carbamoylcholine chloride
1 of 2 reviewers received a sample product or took part in a promotion
Synonym(s):
(2-Hydroxyethyl)trimethylammonium chloride carbamate, Carbachol, Carbamylcholine chloride
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About This Item
Linear Formula:
NH2COOCH2CH2N(Cl)(CH3)3
CAS Number:
Molecular Weight:
182.65
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
200-127-3
MDL number:
Beilstein/REAXYS Number:
3917459
Pricing and availability is not currently available.
Product Name
Carbamoylcholine chloride, ≥98% (titration), crystalline
Quality Level
assay
≥98% (titration)
form
crystalline
color
white
mp
210 °C (dec.) (lit.)
solubility
H2O: 1 g/mL, ethanol: 20 mg/mL
SMILES string
[Cl-].C[N+](C)(C)CCOC(N)=O
InChI
1S/C6H14N2O2.ClH/c1-8(2,3)4-5-10-6(7)9;/h4-5H2,1-3H3,(H-,7,9);1H
InChI key
AIXAANGOTKPUOY-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), CHRNA2(1135)
mouse ... Chrm1(12669)
rat ... Chrm1(25229), Chrm2(81645), Chrm3(24260), Chrna2(170945), Chrna3(25101), Chrna4(25590)
Application
Carbamoylcholine chloride has been used:
- to stimulate insulin secretion in transgenic mice
- to induce contraction of undifferentiated and differentiated human adipose-derived stem cells (hASCs)
- to mediate constriction of iris in pupillary light reflex studies in mice
Biochem/physiol Actions
Non-selective cholinergic agonist that is resistant to the action of cholinesterases; inhibits apoptotic death of cultured neurons, and may induce apoptosis in thymocytes.
Carbachol elicits tear fluid secretion by interacting with muscarinic receptors. It is an analog of acetylcholine and an antiglaucoma drug. In ciliary processes, carbachol along with nitric oxide (NO) regulates Na+ and K+-ATPase activity. It stimulates insulin vesicles transport to the secretory site to increase insulin secretion.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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This Item | |||
|---|---|---|---|
| form crystalline | form powder | form powder or crystals | form powder or crystals |
| assay ≥98% (titration) | assay ≥98% (TLC) | assay ≥99.0% (AT) | assay ≥99.0% (AT) |
| Quality Level 100 | Quality Level 100 | Quality Level 200 | Quality Level 200 |
| solubility H2O: 1 g/mL, ethanol: 20 mg/mL | solubility H2O: 50 mg/mL (solutions undergo rapid, pH-dependent decomposition at pH > 6.) | solubility H2O: 1 M, clear, colorless | solubility H2O: 1 M, clear, colorless |
| color white | color - | color colorless to white | color colorless to white |
| mp 210 °C (dec.) (lit.) | mp 171-173 °C (lit.) | mp 302-305 °C (dec.) (lit.) | mp 302-305 °C (dec.) (lit.) |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Find documentation for the products that you have recently purchased in the Document Library.
Role of the non-neuronal cholinergic system in the eye: a review
Duncan G and Collison DJ
Life Sciences, 72(18-19), 2013-2019 (2003)
Anne Cathrine Nøhr et al.
Scientific reports, 9(1), 3802-3802 (2019-03-09)
GPR139 is an orphan G protein-coupled receptor (GPCR) that is primarily expressed in the brain in regions known to regulate motor control and metabolism. Here, we screened a diverse 4,000 compound library in order to identify GPR139 agonists. We identified
Carbachol and nitric oxide inhibition of Na, K-ATPase activity in bovine ciliary processes
Ellis DZ, et al.
Investigative Ophthalmology & Visual Science, 42(11), 2625-2631 (2001)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C4382-25G | 04061832089799 |
| C4382-1G | 04061835259595 |
| C4382-10G | 04061833492048 |
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What is the difference between Carbamoylcholine chloride Products C4382 and C2409?
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How should Carbamoylcholine chloride, Product C4382, be dissolved?
1 answer-
This product is soluble in water (1000 mg/mL), in ethanol (20 mg/mL), and in methanol (100 mg/mL).
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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