Skip to Content
Merck
All Photos(1)

Documents

B7283

Sigma-Aldrich

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Synonym(s):

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C10H15N3O5 · HCl
CAS Number:
14919-77-8
Molecular Weight:
293.70
EC Number:
238-991-9
MDL number:
MFCD00078571
UNSPSC Code:
12352125
PubChem Substance ID:
24277886
NACRES:
NA.77

product name

Benserazide hydrochloride, ≥98% (HPLC), solid

biological source

synthetic

Assay

≥98% (HPLC)

form

solid

solubility

H2O: 10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

Gene Information

human ... DDC(1644)

Looking for similar products? Visit Product Comparison Guide

General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:
  • to inhibit dopa-decarboxylase
  • to induce dyskinesia
  • to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
  • as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.
Inhibitor of L-aromatic amino acid decarboxylase.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Restoration of the dopamine transporter through cell therapy improves dyskinesia in a rat model of Parkinson?s Disease
Tomas D, et al.
PLoS ONE, 11(4), e0153424-e0153424 (2016)
24 - Extrapyramidal movement disorders and spasticity
Waller DG, et al.
Medical Microbiology, 325-336 (2018)
Developmental and evolutionary basis for drought tolerance of the Anopheles gambiae embryo
Goltsev Y, et al.
Developmental Biology, 330(2), 462-470 (2009)
Benserazide, a dopadecarboxylase inhibitor, suppresses tumor growth by targeting hexokinase 2
Li W, et al.
Journal of Experimental & Clinical Cancer Research, 36(1), 58-58 (2017)
Diana Matheoud et al.
Nature, 571(7766), 565-569 (2019-07-19)
Parkinson's disease is a neurodegenerative disorder with motor symptoms linked to the loss of dopaminergic neurons in the substantia nigra compacta. Although the mechanisms that trigger the loss of dopaminergic neurons are unclear, mitochondrial dysfunction and inflammation are thought to
View All Related Papers

Articles

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

Serotonin Synthesis & Metabolism

Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.

See All

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service