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Actinonin

Name: Actinonin
Brand: SIGMA

≥98% (TLC), powder, leucine aminopeptidase inhibitor

Synonym(s):

3-[[1-[(2-(Hydroxymethyl)-1-pyrrolidinyl)carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic acid

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₃₅N₃O₅

CAS Number:

13434-13-4

Molecular Weight:

385.50

NACRES:

NA.77

PubChem Substance ID:

24278232

UNSPSC Code:

12352200

MDL number:

MFCD00080257

Beilstein/REAXYS Number:

1555250

Assay:

≥98% (TLC)

Form:

powder

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Properties

Product Name

Actinonin,

biological source

synthetic (organic)

Quality Segment

200

assay

≥98% (TLC)

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

storage temp.

−20°C

SMILES string

CCCCCC(CC(=O)NO)C(=O)NC(C(C)C)C(=O)N1CCCC1CO

InChI

1S/C19H35N3O5/c1-4-5-6-8-14(11-16(24)21-27)18(25)20-17(13(2)3)19(26)22-10-7-9-15(22)12-23/h13-15,17,23,27H,4-12H2,1-3H3,(H,20,25)(H,21,24)

InChI key

XJLATMLVMSFZBN-UHFFFAOYSA-N

Gene Information

human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)

Description

General description

Chemical structure: peptide

Application

Actinonin has been used as a control to inhibit meprin-β activity in C57BL/6 mice. It has also been used to study the high-affinity interaction of EcPDF with actinonin by 15N NMR spectroscopy and isothermal titration.

Biochem/physiol Actions

Actinonin is an inhibitor of leucine aminopeptidase. Actinonin has also been used to improve antibacterial activity and antiobesity therapeutics.

Actinonin has inhibitory action against peptide deformylase (PDF). It is effective against Gram-positive and fastidious Gram-negative microorganisms.

Features and Benefits

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Show Differences

1 of 1

This Item	A1276	A6191	I0160
Sigma-Aldrich A6671 Actinonin	Sigma-Aldrich A1276 Amastatin hydrochloride hydrate	Sigma-Aldrich A6191 Antipain dihydrochloride from microbial source	Sigma-Aldrich I0160 Imipenem monohydrate
assay ≥98% (TLC)	assay ≥97% (HPLC)	assay -	assay ≥98% (HPLC)
form powder	form powder	form lyophilized powder	form powder
Quality Level 200	Quality Level 200	Quality Level 300	Quality Level 100
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
solubility ethanol: 50 mg/mL, clear, colorless	solubility methanol: 1 mM (Stock solution stable for 1 month at −20 °C. Working solution stable for 1 day.)	solubility H₂O: 50 mg/mL, 1-butanol: soluble, 1-propanol: soluble, DMSO: soluble, ethanol: soluble, methanol: soluble	solubility -
Gene Information human ... ANPEP(290), DPP4(1803), ECE1(1889), LAP3(51056)	Gene Information -	Gene Information -	Gene Information -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000548798

0000520969

0000520970

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Global Trade Item Number

SKU	GTIN
A6671-25MG	04061833382646
A6671-10MG	04061833258477

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